Evidence map›Paper›PMID 41691134›Full record

ReviewArchives of gynecology and obstetrics2026

The research on the relationship between mesenchymal stromal cell exosomes and recurrent spontaneous abortion.

Chenman Zhao, Junqing Wang, Wenqiong Liu

Abstract readReview
In one paragraph

Review in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chenman ZhaoShandong University of Traditional Chinese Medicine, Ji Nan, China.ORCID 0009-0005-0526-0949
Junqing WangThe Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji Nan, China.
Wenqiong LiuAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji Nan, China. 2621504134@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo clarify the association between mesenchymal stromal cell exosomes (MSC-exosomes) and recurrent spontaneous abortion (RSA) Clarify the biological characteristics of MSC-exosomes and their potential regulatory functions in pregnancy maintenance.

methodsBy using the literature review method combined with the published relevant experimental research results, the biological characteristics of MSC-exosomes were systematically sorted out and analyzed to explore their potential mechanism of action in the process of pregnancy maintenance. The results show that MSC-exosomes can participate in the key processes of pregnancy maintenance by regulating the immune microenvironment at the maternal-fetal interface, promoting local angiogenesis and maintaining the normal physiological functions of trophoblast cells. The content of MSC-exosomes in the body shows a dynamic changing trend during pregnancy. A large number of studies have confirmed that MSC-exosomes are closely related to the establishment and maintenance of normal pregnancy and the occurrence and development of pathological pregnancy.

conclusionIn-depth exploration of the intrinsic association and mechanism of action between MSC-exosomes and RSA can provide a new perspective for the study of the pathogenesis of RSA, and at the same time offer potential biomarkers and therapeutic targets for the clinical diagnosis and targeted therapy of RSA, which has significant theoretical value and clinical significance.

Indexed as

Abortion, HabitualExosomesMesenchymal Stem CellsFemaleHumansPregnancyPregnancy MaintenanceTrophoblastsAngiogenesisExosomeImmune regulationMesenchymal stromal cellRecurrent spontaneous abortion

Identifiers

PMID41691134
PMCPMC12906519

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.