Evidence map›Paper›PMID 41691099›Full record

Trial reportScientific reports2026

Postoperative pain after emergency pulpectomy with or without photobiomodulation in symptomatic irreversible pulpitis A randomized clinical trial.

Sérgio Alves Guida Freitas-Júnior, Meire Coelho Ferreira, Amanda Palmeira Arruda Nogueira, Cláudia de Castro Rizzi, Wallace Vieira Mendes, Etevaldo Matos Maia-Filho, Giulio Gavini, Renata Grazziotin-Soares, Ceci Nunes Carvalho

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sérgio Alves Guida Freitas-JúniorDentistry Postgraduate Program, University Ceuma, R. Josué Montello, 1, Renascença II, São Luís, 65075-120, MA, Brazil.
Meire Coelho FerreiraDentistry Postgraduate Program, University Ceuma, R. Josué Montello, 1, Renascença II, São Luís, 65075-120, MA, Brazil.
Amanda Palmeira Arruda NogueiraDentistry Postgraduate Program, University Ceuma, R. Josué Montello, 1, Renascença II, São Luís, 65075-120, MA, Brazil.
Cláudia de Castro RizziDentistry Graduate Program, Faculdade Florence, São Luís, MA, Brazil.
Wallace Vieira MendesDentistry Postgraduate Program, University Ceuma, R. Josué Montello, 1, Renascença II, São Luís, 65075-120, MA, Brazil.
Etevaldo Matos Maia-FilhoDentistry Postgraduate Program, University Ceuma, R. Josué Montello, 1, Renascença II, São Luís, 65075-120, MA, Brazil.
Giulio GaviniDepartment of Restorative Dentistry, School of Dentistry, University of São Paulo (FOUSP), Av. Lineu Prestes, 2227, São Paulo, 05508-000, Brazil.
Renata Grazziotin-SoaresDivision of Endodontics, Dept. of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, UBC, Vancouver, Canada.
Ceci Nunes CarvalhoDentistry Postgraduate Program, University Ceuma, R. Josué Montello, 1, Renascença II, São Luís, 65075-120, MA, Brazil. ceci.carvalho@ceuma.br.

Funding

Foundation for Research and Scientific and Technological Development of Maranhão - FAPEMA, Brazil FAPEMA BEPP-02471/23-Edital 04/2023; UNIVERSAL-06372/22 Edital 02/2022
6 · The paper itself

Abstract

To evaluate postoperative pain following emergency pulpectomy in permanent teeth diagnosed with symptomatic irreversible pulpitis and to compare outcomes with or without adjunctive low-level laser therapy (LLLT). This parallel, randomized, single-blind clinical trial included 70 patients with permanent teeth diagnosed with symptomatic irreversible pulpitis. Patients were randomly assigned to two groups (n = 35 each): the experimental group received gallium-aluminum-arsenide laser therapy (808 nm, 100 mW), while the control group received no laser intervention. Postoperative pain was assessed using the Numerical Rating Scale (NRS-10) and the Visual Analogue Scale (VAS). Bite sensitivity was evaluated before and after emergency treatment. Demographic characteristics and analgesic intake were recorded. The primary outcome was postoperative spontaneous pain assessed at multiple time points. Secondary outcomes included bite sensitivity and analgesic intake. Time-dependent reductions in postoperative pain were observed in both groups. Inter-group comparisons showed statistically significant differences at isolated time points (12 and 24 h), with higher pain scores in the experimental group; however, these differences did not translate into a significant overall treatment effect. Longitudinal analysis accounting for repeated measures demonstrated a significant effect of time (p = 0.001), while treatment group was not a significant determinant of postoperative pain. Effect estimates are presented with 95% confidence intervals. Within the limitations of this pragmatic emergency-care study, adjunctive low-level laser therapy was not associated with a reduction in postoperative pain in permanent teeth with symptomatic irreversible pulpitis.

Indexed as

Low-Level Light TherapyPostoperative PainPulpectomyPulpitisAdultFemaleHumansMaleMiddle AgedPain MeasurementSingle-Blind MethodTreatment OutcomeYoung AdultEndodonticsIrreversible pulpitisLow-level laser therapyPhotobiomodulationPostoperative pain

Identifiers

PMID41691099
PMCPMC12992582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.