Evidence map›Paper›PMID 41690929›Full record

ArticleNature communications2026

Serotonin modulates nucleus accumbens circuits to suppress aggression in mice.

Zihui Zhang, Gavin C Touponse, Pia J Alderman, Teema Yassine, Matthew B Pomrenze, Troy W Harris, Amei N Shank, Robert C Malenka, Neir Eshel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Zihui ZhangDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8002-9396
Gavin C TouponseDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8087-3351
Pia J AldermanDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Teema YassineDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Matthew B PomrenzeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9032-5911
Troy W HarrisDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0009-0005-3523-9382
Amei N ShankDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Robert C MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. malenka@stanford.edu.ORCID http://orcid.org/0000-0002-5428-5211
Neir EshelDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. neshel@stanford.edu.ORCID http://orcid.org/0000-0002-5976-2013

Funding

Serotonergic modulation of aggressive and prosocial behaviorsR01MH138645 · NIMH · STANFORD UNIVERSITY · PI Neir Eshel · 2025 to 2026
$1.3M
Neural circuits of frustrationK08MH123791 · NIMH · STANFORD UNIVERSITY · PI ESHEL, NEIR · 2020 to 2024
$1.2M
Modulation of protracted opioid withdrawal by dorsal raphe dynorphin neuronsK99DA056573 · NIDA · STANFORD UNIVERSITY · PI POMRENZE, MATTHEW B · 2022 to 2023
$317k
NIDA NIH HHS K99 DA056573NIMH NIH HHS K08 MH123791NIMH NIH HHS R01 MH138645U.S. Department of Health & Human Services | National Institutes of Health (NIH) K08MH123791U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH138645
6 · The paper itself

Abstract

Serotonin (5-hydroxytryptamine; 5HT) has long been considered anti-aggressive, but the mechanisms by which 5HT regulates downstream circuits to control aggression remain unclear. Combining fiber photometry, optogenetics, and miniaturized microscope recordings in double-transgenic male mice, we find that 5HT levels ramp up in the nucleus accumbens during aggression, inhibiting a subset of D1 medium spiny neurons to suppress attacks. Our results reveal a novel 5HT-mediated neuromodulatory mechanism for limiting aggressive behavior.

Indexed as

AggressionNucleus AccumbensSerotoninAnimalsMaleMedium Spiny NeuronsMiceMice, Inbred C57BLMice, TransgenicOptogeneticsReceptors, Dopamine D1Receptors, Dopamine D1Serotonin

Identifiers

PMID41690929
PMCPMC13018284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.