Evidence map›Paper›PMID 41690906›Full record

ArticleNature communications2026

Spatiotemporal interplay between epithelial and mesenchymal cells drives human dentinogenesis.

Wei Wei, Chuan Wu, Jing Sun, Mengjie Han, Xiuge Gu, Hanzhang Zhou, Xiaoshan Wu, Zongshan Shen, Chunmei Zhang, Jinsong Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wei Wei *Laboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-5874-3825
Chuan Wu *Laboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.ORCID http://orcid.org/0009-0003-5990-0310
Jing SunLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Mengjie HanDepartment of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Xiuge GuLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Hanzhang ZhouDepartment of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Xiaoshan WuLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Zongshan ShenLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Chunmei ZhangLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Jinsong WangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Lei HuLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China.
Lanrong LuoDepartment of Reproductive Regulation, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Yuanyuan ZhangDepartment of Reproductive Regulation, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Lina HuDepartment of Reproductive Regulation, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Songlin WangLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China. slwang@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-7066-2654
Ran ZhangLaboratory of Oral Health and Homeostatic Medicine, School of Stomatology and Beijing Stomatological Hospital and Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China. rani@bjmu.edu.cn.ORCID http://orcid.org/0000-0001-5815-2689

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tooth dentin, secreted by odontoblasts, constitutes most of the tooth structure and provides support and sensory function. However, dentin defects are common and irreparable once they exceed a critical threshold. Human dentin develops from dental papilla (DP) cells under the guidance of the dental epithelium (DE). Here, we present a human tooth development atlas from initiation to erupted stage using single-cell RNA sequencing and spatial transcriptomics, focusing on epithelial-mesenchymal interactions. This atlas reveals that DE orchestrates DP differentiation in a WNT-NOTCH sequential activation model and identifies the key signaling molecules. DLX6-AS1

Indexed as

DentinogenesisEpithelial CellsMesenchymal Stem CellsAdultAnimalsCell DifferentiationDental PapillaDental PulpDentinGene Expression Regulation, DevelopmentalHumansOdontoblastsSingle-Cell Gene Expression AnalysisTooth

Identifiers

PMID41690906
PMCPMC13018595

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.