Evidence map›Paper›PMID 41690710›Full record

ArticleJournal of medical genetics2026

Later age of natural menopause among women with the pathogenic

Maartje A C Schreurs, Antoinette Hollestelle, Muriel A Adank, Yvonne Louwers, Christi J van Asperen, Margreet G E M Ausems, Irma van de Beek, Margriet J Collee, Charlotte J Dommering, Encarna B Gómez García and 7 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maartje A C SchreursDepartment of Medical Oncology, Erasmus MC Cancer Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1826-5344
Antoinette HollestelleDepartment of Medical Oncology, Erasmus MC Cancer Center, Rotterdam, The Netherlands.
Muriel A AdankDepartment of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Yvonne LouwersDivision of Reproductive Endocrinology and Infertility, Erasmus MC, Rotterdam, The Netherlands.
Christi J van AsperenDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Margreet G E M AusemsDepartment of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Irma van de BeekDepartment of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Margriet J ColleeDepartment of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Charlotte J DommeringDepartment of Human Genetics, Amsterdam UMC, Amsterdam, The Netherlands.
Encarna B Gómez GarcíaClinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Marijke R WeversRadboud University Medical Center, Nijmegen, The Netherlands.
Emma M VieveenDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0009-0007-9208-5521
Refika YigitDepartment of Obstetrics and Gynecology, University of Groningen, Groningen, The Netherlands.
Marjanka K SchmidtMolecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Jenny A VisserDepartment of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Maartje J HooningDepartment of Medical Oncology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands m.hooning@erasmusmc.nl.
Hebon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe average age of natural menopause (ANM) for European women is 50-52 years. Reproductive risk and lifestyle factors have been found to be associated with ANM. Furthermore, a genome-wide association study found that women with a

methodsAs part of the HEreditary Breast and Ovarian cancer Netherlands (Hebon) study, all women who underwent genetic testing for pathogenic variants associated with breast or ovarian cancer were invited to participate and complete a questionnaire on established risk factors. We compared the reported ANM between groups and within selected birth cohorts. HRs and 95% CIs for the association of

resultsWe included 661

conclusion

Indexed as

Breast NeoplasmsCheckpoint Kinase 2MenopauseOvarian NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHeterozygoteHumansMiddle AgedNetherlandsRisk FactorsCheckpoint Kinase 2CHEK2 protein, humanGenetics, Population

Identifiers

PMID41690710
PMCPMC13151450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.