Evidence map›Paper›PMID 41690592›Full record

ArticleThe Journal of biological chemistry2026

Oligomer-dependent and oligomer-independent pathogenesis of muscular dystrophy-associated mutations within the penta-EF-hand domain of calpain-3.

Chihiro Hisatsune, Fumiko Shinkai-Ouchi, Shoji Hata, Yasuko Ono

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chihiro HisatsuneCalpain group, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan. Electronic address: hisatsune-ch@igakuken.or.jp.
Fumiko Shinkai-OuchiCalpain group, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan.
Shoji HataCalpain group, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan.
Yasuko OnoCalpain group, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan; Research Administration Center, Saitama Medical University, Saitama, Japan. Electronic address: ono.ys.2025@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limb-girdle muscular dystrophy R1 (LGMDR1) is an autosomal recessive disorder caused by dysfunction of calpain-3 (CAPN3; also known as p94), a muscle-specific, Ca

Indexed as

CalpainEF Hand MotifsMuscle ProteinsMuscular Dystrophies, Limb-GirdleMutationAnimalsHumansMiceProtein DomainsCalpainCAPN3 protein, humanCapn3 protein, mouseMuscle ProteinscalpainM-bandmuscular dystrophyoligomerpenta-EF-hand motifsarcomere

Identifiers

PMID41690592
PMCPMC12996665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.