Evidence map›Paper›PMID 41690568›Full record

ArticleNeuroscience2026

Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.

Ted K Doykos, Taylor Yamauchi, Anna Buteau, Spencer Hanson, Joshua T Dudman, Gidon Felsen, Elizabeth A Stubblefield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ted K DoykosDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Taylor YamauchiDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Anna ButeauDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Spencer HansonDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Joshua T DudmanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Gidon FelsenDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO 80045, USA; Janelia Research Campus Visitor Program, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. Electronic address: gidon.felsen@cuanschutz.edu.
Elizabeth A StubblefieldDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Janelia Research Campus Visitor Program, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. Electronic address: elizabeth.stubblefield@colorado.edu.

Funding

Functional neural circuitry for decision making in the superior colliculusR01NS079518 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GIDON S FELSEN · 2012 to 2026
$5.2M
Neural circuits for adaptively biasing decision makingR01NS129608 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GIDON S FELSEN · 2023 to 2026
$1.4M
Functional neural circuitry underlying the selection of targets for movement in the superior colliculusF31NS103305 · NINDS · UNIVERSITY OF COLORADO DENVER · PI ESSIG, JACLYN L · 2017 to 2020
$99k
NINDS NIH HHS F31 NS103305NINDS NIH HHS R01 NS079518NINDS NIH HHS R01 NS129608
6 · The paper itself

Abstract

Coordinated lateralized movements are critical for natural orienting behaviors, but their neural bases remain poorly understood. The deep superior colliculus (dSC) integrates a wide range of inputs to select targets for orienting movements and coordinates downstream activity to initiate and execute movement. The substantia nigra pars reticulata (SNr) is thought to disinhibit dSC to facilitate movement, but much remains unknown about the relationship between SNr activity, dSC activity, and movement. We recorded from both regions using high-density probes in head-fixed mice performing directional orienting tasks. We found that dSC and SNr activity reflected task variables preceding and throughout movement. However, the direction-dependence of dSC activity was weaker than in other orienting behaviors, and the relationship between movement-related dSC and SNr activity was inconsistent with disinhibition of dSC determining the initiation or direction of movement. Analyses of similar data curated by the International Brain Laboratory yielded consistent results. These findings suggest diverse roles for modulatory input from SNr to dSC in shaping motor behavior.

Indexed as

ForelimbOrientationPars ReticulataSuperior ColliculiAnimalsMaleMiceMice, Inbred C57BLMovementNeuronsDecision makingDirectional orienting movementsHead-fixed behaviorNeuropixels recordingsPrior history

Identifiers

PMID41690568
PMCPMC13455206

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.