Evidence map›Paper›PMID 41690258›Full record

ArticleAddictive behaviors2026

Infant caregiving, relational factors, mood, and pain in perinatal opioid use disorder: A prospective cohort with ecological momentary assessment.

Alicia M Allen, Linnea B Linde-Krieger, James Baurley, Jendar Deschenes, Stephanie Mallahan, Alma Anderson, Stacey Tecot, Lela Rankin

Abstract read
In one paragraph

Article in Addictive behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alicia M AllenNational Center for Opioid Research and Clinical Efficacy, Arkansas Children's Research Institute, 13 Children's Way, Slot 842, Little Rock, AR 72202, USA(1); Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, 1300 South Medical Drive, Little Rock, AR 72202, USA(1); Department of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, 655 N Alvernon Way, Suite 228, Tucson, AZ 85711, USA. Electronic address: allena3@archildrens.org.
Linnea B Linde-KriegerDepartment of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, 655 N Alvernon Way, Suite 228, Tucson, AZ 85711, USA; School of Social Work, Arizona State University, 411 N Central Ave, #800, Phoenix, AZ 85004, USA(1).
James BaurleyBioRealm LLC, 19330 Rim of the World Drive, Monument, CO 80132, USA.
Jendar DeschenesDepartment of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, 655 N Alvernon Way, Suite 228, Tucson, AZ 85711, USA.
Stephanie MallahanDepartment of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, 655 N Alvernon Way, Suite 228, Tucson, AZ 85711, USA.
Alma AndersonDepartment of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, 655 N Alvernon Way, Suite 228, Tucson, AZ 85711, USA.
Stacey TecotLaboratory for the Evolutionary Endocrinology of Primates, University of Arizona, P.O. Box 210030, Tucson, AZ 85721, USA; School of Anthropology, University of Arizona, P.O. Box 210030, Tucson, AZ 85721, USA.
Lela RankinSchool of Social Work, Arizona State University, 411 N Central Ave, #800, Phoenix, AZ 85004, USA(1).

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Hormonal Response to Infant Caregiving: A Novel Strategy to Break the Opioid Relapse Cycle during the Postpartum PeriodDP2HD105541 · NICHD · UNIVERSITY OF ARIZONA · PI ALLEN, ALICIA M · 2020 to 2020
$2.3M
NCATS NIH HHS UL1 TR000445NICHD NIH HHS DP2 HD105541
6 · The paper itself

Abstract

Evidence-based opioid use disorder (OUD) relapse prevention interventions designed to the unique needs of the postpartum period are lacking. We aimed to identify novel intervention targets using ecological momentary assessment (EMA) with Bayesian mixed-effects models to assess infant caregiving (e.g., skin-to-skin contact), relational factors (e.g., loneliness), and individual factors (e.g., pain): (1) by OUD status, and (2) in relation to craving and coping. Participants with and without OUD (OUD+ and OUD-, respectively) were followed from late pregnancy to postpartum week 12 with daily EMA assessing infant caregiving, relational factors, individual factors, craving for non-therapeutic opioids (e.g., heroin), craving for therapeutic opioids (e.g., methadone), and coping with cravings. Participants (n = 61) were 29.4 ± 5.1 years old. Compared to OUD- (n = 18), OUD+(n = 43) had greater infant-focused anxiety (β = 0.24, 95% CI: 0.002, 0.48) and well-being stress (β = 0.32; 95% CI: 0.02, 0.64). Coping with cravings declined over time (β = -0.38, 95% CI: -0.77, -0.01) whereas opioid cravings did not. Numerous associations were identified including, but not limited to, non-therapeutic craving with infant-focused anxiety (β = 1.95; 95% CI: 0.33, 3.55) and pain (β = 0.08; 95% CI: 0.03, 0.13), therapeutic craving with tangible support (β = 3.99; 95% CI: 0.56, 7.48) and work-related stress (β = 1.88; 95% CI: 0.63, 3.14), and coping with cravings with skin-to-skin contact (β = 0.07; 95% CI: 0.03, 0.11) and general well-being stress (β = -2.07; 95% CI: -4.12, -0.01). Several modifiable risk factors had unique and meaningful associations with opioid cravings and coping with craving. Future research is needed to replicate these observations in diverse samples and examine the applicability to postpartum OUD recovery support.

Indexed as

AffectInfant CareOpioid-Related DisordersPainPregnancy ComplicationsAdaptation, PsychologicalAdultAnxietyBayes TheoremCoping SkillsCravingEcological Momentary AssessmentFemaleHumansInfantInfant, NewbornBayesian analysesCravingEcological momentary assessmentOpioid use disorderPerinatalPostpartum

Identifiers

PMID41690258
PMCPMC12936973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.