Evidence map›Paper›PMID 41690207›Full record

ArticleHuman immunology2026

Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers.

Andreas Stephanou, Madhav Mantri, Divya Shankaranarayanan, Carol Li, Mila Lagman, Jenny Xiang, Chendong Pan, Yanjie Sun, Thangamani Muthukumar, Khaled Machaca and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Andreas StephanouNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Madhav MantriNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Divya ShankaranarayananDivision of Nephrology and Hypertension, George Washington University, Washington DC, USA.
Carol LiDivision of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA.
Mila LagmanDivision of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA.
Jenny XiangGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, USA.
Chendong PanGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, USA.
Yanjie SunGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, USA.
Thangamani MuthukumarDivision of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA.
Khaled MachacaCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar; Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Iwijn De VlaminckNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address: vlaminck@cornell.edu.
Manikkam SuthanthiranDivision of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA. Electronic address: msuthan@med.cornell.edu.

Funding

Biomolecular Markers for Safe Minimization of ImmunosuppressionR37AI051652 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SUTHANTHIRAN, MANIKKAM · 2009 to 2021
$4.7M
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4M
Urine mRNA Profiling for Renal Allograft SurveillanceR01AI051652 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SUTHANTHIRAN, MANIKKAM · 2002 to 2006
$2.3M
Cell-Free DNA in Peritoneal Fluid as a Novel and Versatile Analyte for Monitoring PeritonitisR21AI164093 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE VLAMINCK, IWIJN, LEE, JOHN RICHARD · 2021 to 2022
$481k
NIAID NIH HHS R01 AI051652NIAID NIH HHS R01 AI151059NIAID NIH HHS R21 AI164093NIAID NIH HHS R37 AI051652
6 · The paper itself

Abstract

Store-operated calcium entry (SOCE) plays a critical role in regulating intracellular calcium signaling and is essential for immune cell functions. SOCE blockade with the pyrazole derivative BTP2 has been explored as an anti-inflammatory strategy in preclinical models, and Zegocractin (CM4620) is under clinical investigation as a CRAC channel inhibitor with activity in multiple tissues, including immune cells. However, the cell type-specific consequences of SOCE blockade under defined activation contexts remain incompletely understood. Here, we used multiplexed single-cell RNA sequencing to investigate the effects of two prototypic SOCE blockers, BTP2 and CM4620, on polyclonally stimulated, normal human peripheral blood mononuclear cells (PBMCs) in a phytohemagglutinin (PHA)-driven T-cell activation model. The data revealed that SOCE blockade suppressed cytotoxicity-associated transcriptional programs in CD8

Indexed as

Calcium Channel BlockersCalcium ChannelsCD8-Positive T-LymphocytesInflammationKiller Cells, NaturalAnilidesCalciumCalcium SignalingCells, CulturedGene Expression ProfilingHumansLeukocytes, MononuclearLymphocyte ActivationPyrazolesSingle-Cell AnalysisSingle-Cell Gene Expression Analysis4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilideAnilidesCalciumCalcium Channel BlockersCalcium ChannelsPyrazolesThiadiazoles

Identifiers

PMID41690207
PMCPMC13478930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.