ArticleNeoplasia (New York, N.Y.)2026
White-to-brown adipose switching promotes bladder cancer progression.
Article in Neoplasia (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Identification of alpha1-oleate as a potent regulator of adipokine-dependent metabolism, in bladder cancer tissue.Cancer & metabolism · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The invasion of bladder cancer into perivesical adipose tissue represents a watershed event in tumor progression, accompanied by a dramatic deterioration in clinical outcomes. However, the underlying molecular mechanisms governing this cancer-adipose tissue crosstalk remain poorly elucidated. Here, we systematically characterize a bidirectional regulatory network between bladder cancer cells and perivesical adipocytes. Our findings demonstrate that bladder cancer cells secreted parathyroid-hormone-related protein (PTHrP), which induces browning of perivesical adipose tissue through activation of protein kinase A (PKA) signaling. Conversely, thermogenesis induced by browning perivesical adipose tissues leads to the release of excessive free fatty acids. These free fatty acids are subsequently taken up by bladder cancer cells, where they promote lipid metabolic reprogramming and thereby enhance cancer cell proliferation, invasion, and metastatic potential. In vivo experiments further validate that treatment with H89, a specific PKA inhibitor, effectively reverses perivesical adipose tissue browning and attenuates bladder cancer progression. Collectively, our data clarify that PTHrP secreted by bladder cancer cells drives perivesical adipose tissue browning to accelerate cancer progression, providing a novel potential therapeutic target for bladder cancer intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.