Evidence map›Paper›PMID 41689914›Full record

ArticleThe journal of physiological sciences : JPS2026

Effects of systemic ventricular assist combined with fenestration in failing Fontan: A theoretical analysis.

Shuji Shimizu, Yasuhiro Kotani, Naohiro Horio, Eiri Kisamori, Yoshinori Miyahara, Koji Uemura, Toshiaki Shishido, Shingo Kasahara

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In one paragraph

Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuji ShimizuDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan; Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan. Electronic address: shujismz@ncvc.go.jp.
Yasuhiro KotaniDepartment of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Naohiro HorioDepartment of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan; Pediatric Heart Disease and Adult Congenital Heart Disease Center, Showa Medical University Hospital, Tokyo, Japan.
Eiri KisamoriDepartment of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Yoshinori MiyaharaPediatric Heart Disease and Adult Congenital Heart Disease Center, Showa Medical University Hospital, Tokyo, Japan.
Koji UemuraDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Toshiaki ShishidoDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Shingo KasaharaDepartment of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biventricular assist for failing Fontan circulation remains challenging. Because fenestration effectively reduces stressed blood volume and central venous pressure in Fontan patients with increased pulmonary vascular resistance (PVR), systemic ventricular assist device (VAD) combined with fenestration may improve hemodynamics in failing Fontan patients with increased PVR who would require biventricular assist. To validate this hypothesis, we performed a computational hemodynamic simulation of the failing Fontan circulation using a lumped parameter model. We compared hemodynamic variables between the models with and without fenestration while the PVR index was increased sequentially from 3.01 to 6.81 Wood Units m

Indexed as

Fontan ProcedureHeart-Assist DevicesBlood VolumeComputer SimulationHemodynamicsHumansModels, CardiovascularVascular ResistanceFenestrationFontan circulationHemodynamic simulationPulmonary vascular resistanceVentricular assist device

Identifiers

PMID41689914
PMCPMC12925447

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.