Evidence map›Paper›PMID 41689797›Full record

ArticleCell reports2026

Proteasome activity maintains cell-type-specific gene expression.

Xiuxiu Lu, Vasty Osei-Amponsa, Germán Michelis, Rithik E Castelino, Hitendra Negi, Sudipto Das, Jesse L Turner, Julianna C King, Daniel Martin, Yan Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiuxiu LuProtein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Vasty Osei-AmponsaProtein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Germán MichelisStem Cell Biochemistry Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Rithik E CastelinoProtein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Hitendra NegiProtein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Sudipto DasProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Jesse L TurnerGenome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Julianna C KingGenome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Daniel MartinNIDCD/NIDCR Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.
Yan WangMass Spectrometry Facility, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Thorkell AndressonProtein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
Raj ChariGenome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Achim WernerStem Cell Biochemistry Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Kylie J WaltersProtein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. Electronic address: kylie.walters@nih.gov.

Funding

Ubiquitin signaling for protein degradationZIABC011490 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WALTERS, KYLIE · 2013 to 2025
$21.1M
Ubiquitin-dependent cell-fate decisions during human development and diseaseZIADE000749 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WERNER, ACHIM · 2018 to 2025
$14.1M
Myosin VI: a new ubiquitin receptorZIABC011627 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WALTERS, KYLIE · 2015 to 2025
$4.6M
Mass Spectrometry FacilityZIADE000751 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WANG, YAN · 2019 to 2019
$193k
Intramural NIH HHS ZIA BC011490Intramural NIH HHS ZIA BC011627Intramural NIH HHS ZIA DE000749Intramural NIH HHS ZIA DE000751
6 · The paper itself

Abstract

Regulated proteolysis in eukaryotes relies on the ubiquitin-proteasome system, which is critical to myriad cellular functions, including protein quality control, cell cycle regulation, and DNA repair. Here, we provide evidence that proteasome activity is also essential for maintaining cell identity. This finding was made by evaluating the impact of losing the ubiquitin-binding activity of proteasome substrate receptor hRpn10/PSMD4. The most dysregulated proteins in cells that express hRpn10 truncated before its ubiquitin interaction motifs (hRpn10

Indexed as

Gene Expression RegulationProteasome Endopeptidase ComplexAnimalsHumansOrgan SpecificityProteolysisTranscription, GeneticUbiquitinProteasome Endopeptidase ComplexUbiquitincell identityCP: molecular biologygene expressionOTUD5proteasomeprotein degradationPSMD4Rpn10tissue specificitytranscriptional regulationubiquitin

Identifiers

PMID41689797
PMCPMC13006838

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.