Observational studyActa neurologica Belgica2026
Detection of chronic cerebellar and cerebral very small cortical infarctions on T2 and FLAIR 1.5T MRI.
Observational study in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06218576 (Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions ( CMI )
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDetection rate of chronic cerebral very small cortical infarctions (VSCI) is low. Few data are available on chronic cerebellar VSCI. Our aim was to study the ability of 1.5T FLAIR and T2-weighted imaging to detect chronic VSCI and compare cerebral and cerebellar VSCI location.
methodsWe prospectively included stroke patients with ≥ 1 acute cerebral or cerebellar VSCI ≤ 10 mm on DWI. Follow-up FLAIR and T2-weighted imaging with the same 1.5T-magnet was performed after six months. Images were evaluated unblinded to initial MRI to detect signal changes at the same location as initial acute VSCI. Variables influencing chronic VSCI detection were analyzed in uni- and multivariate analyses.
resultsWe analyzed 57 patients (median age 65, 44% women) with 111 acute VSCI on initial MRI. These constituted 47 cerebellar and 64 cerebral acute VSCI, with median DWI size of 5.9 mm and initial FLAIR positivity of 70%, without difference between cerebellar and cerebral location. On 6-month follow-up MRI, chronic VSCI detection on FLAIR and T2 was similar for cerebral lesions (p = 0.81), whereas for cerebellar lesions T2 showed a 2.4-fold higher detection rate than FLAIR (p < 0.0001). Univariate analysis using a logistic mixed model for T2 detection of chronic VSCI was associated with cerebellar VSCI location (p < 0.0001) and hypertension history (p = 0.008). Multivariate analysis confirmed the strong association between cerebellar location and T2 detection of chronic VSCI (p < 0.0001, AOR = 7.25, 95% CI = 2.83-18.56) adjusted for hypertension.
conclusionCompared to FLAIR, T2-weighted imaging shows highest detection rates for cerebellar VSCI, with cerebellar VSCI location as strongest predictor of chronic VSCI detection. CLINICAL
trial registrationURL http//www. CLINICALTRIALS: gov. Unique identifier NCT06218576.
Indexed as
Identifiers
41689755What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.