Evidence map›Paper›PMID 41689712›Full record

ReviewMolecular and cellular biochemistry2026

The role and mechanism of histone deacetylase in COPD.

Huifang Tang, Qian Gao, Shu Xie

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Huifang TangSchool of Exercise and Health, Shanghai University of Sport, No. 650 Qingyuanhuan Road, Yangpu District, Shanghai, 200438, China.
Qian GaoSchool of Exercise and Health, Shanghai University of Sport, No. 650 Qingyuanhuan Road, Yangpu District, Shanghai, 200438, China.
Shu XieSchool of Exercise and Health, Shanghai University of Sport, No. 650 Qingyuanhuan Road, Yangpu District, Shanghai, 200438, China. xieshu@sus.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a major global health challenge characterized by persistent airflow limitation. Persistent chronic inflammation serves as the primary driver of its pathogenesis, leading to key structural and functional impairments, including airway remodeling, emphysema, and skeletal muscle dysfunction. Histone deacetylases (HDACs), a class of enzymes crucial for epigenetic regulation, play a pivotal role in the progression of COPD. This review provides a systematic overview of the structural and functional characteristics of HDACs and explores their involvement in the multifaceted pathology of the disease. Given their potential as therapeutic targets, a comprehensive understanding of HDAC-mediated mechanisms may provide a rationale for developing novel HDAC inhibitors and advancing treatment strategies for COPD.

Indexed as

Airway RemodelingEpigenesis, GeneticHistone Deacetylase InhibitorsHistone DeacetylasesPulmonary Disease, Chronic ObstructiveAnimalsHumansHistone Deacetylase InhibitorsHistone DeacetylasesAirway remodelingChronic obstructive pulmonary diseaseEmphysemaHistone deacetylasesInflammationSkeletal muscle dysfunction

Identifiers

PMID41689712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.