Evidence map›Paper›PMID 41689689›Full record

ArticleCVIR endovascular2026

Vessel and balloon sizing in the IN.PACT AV access trial: post-hoc analysis of procedural characteristics and outcomes.

Andrew Holden, Hiroaki Haruguchi, Kotaro Suemitsu, Naoko Isogai, Jeffrey Hull, Bret N Wiechmann, Hong Wang, Bridget Wall, Robert Lookstein, IN.PACT AV Access Investigators

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CVIR endovascular, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03041467 (Randomized Study of IN.PACT™ AV Access Paclitaxel-Coated Percutaneous Transluminal Angioplasty), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03041467 nacompletednot on this map

Randomized Study of IN.PACT™ AV Access Paclitaxel-Coated Percutaneous Transluminal Angioplasty (PTA) Balloon vs. Standard PTA for the Treatment of Obstructive Lesions in the Native Arteriovenous Dialysis Fistulae (AVF)

TypeinterventionalSponsorMedtronic EndovascularRan2017 to 2023Enrolled330ConditionsArteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Arteriovenous Fistula, FistulaArmsIN.PACT AV DCB, Standard Balloon Angioplasty
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew HoldenDepartment of Interventional Radiology, Auckland Hospital, Auckland, New Zealand. Andrew.Holden@TeWhatuOra.govt.nz.ORCID http://orcid.org/0000-0002-8170-4960
Hiroaki HaruguchiHaruguchi Vascular Access Clinic, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5713-987X
Kotaro SuemitsuOsaka Keisatsu Hospital, Osaka, Japan.ORCID http://orcid.org/0000-0002-4251-5315
Naoko IsogaiShonan Kamakura General Hospital, Kanagawa, Japan.ORCID http://orcid.org/0000-0003-3332-2527
Jeffrey HullRichmond Vascular Center, Richmond, VA, USA.ORCID http://orcid.org/0000-0003-4094-5810
Bret N WiechmannVascular and Interventional Physicians, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-7022-497X
Hong WangMedtronic, Plymouth, MN, USA.ORCID http://orcid.org/0000-0001-5424-3946
Bridget WallMedtronic, Plymouth, MN, USA.ORCID http://orcid.org/0000-0001-5511-5305
Robert LooksteinDepartment of Diagnostic, Molecular, and Interventional Radiology at the Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
IN.PACT AV Access Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug-coated balloons (DCBs) have demonstrated effectiveness and safety in the treatment of dysfunctional arteriovenous fistulas used for hemodialysis in larger randomized studies; however, the patient and lesion profiles that have the best DCB outcomes remain undefined. Pivotal trials with core lab adjudication are ideal to generate hypotheses for future studies of intra-procedural characteristics given they include both site-reported and independently assessed data. The IN.PACT AV Access Trial randomized 330 patients 1:1 to treatment with a DCB (n = 170) or uncoated percutaneous transluminal angioplasty (PTA; n = 160). This exploratory post-hoc analysis investigated core lab adjudicated vessel sizing in the context of target lesion primary patency (TLPP) outcomes through 36 months. Participants were split into groups by median reference vessel diameter (RVD).

resultsThe IN.PACT AV Access Trial randomized 330 patients 1:1 to treatment with a DCB (n = 170) or uncoated percutaneous transluminal angioplasty (PTA; n = 160). This exploratory post-hoc analysis investigated core lab adjudicated vessel sizing in the context of target lesion primary patency (TLPP) outcomes through 36 months. Participants were split into groups by median reference vessel diameter (RVD).

conclusionsThis post hoc analysis identified that intra-procedural sizing decisions have the potential to positively impact outcomes in patients with dysfunctional fistula lesions. These findings warrant further prospective evaluation to define optimal DCB sizing strategies.

trial registrationNCT03041467 . Registered 25 April 2017. LEVEL OF EVIDENCE: 3:

Indexed as

AngiogramAngioplastyDialysisDialysis accessEnd stage renal diseaseHemodialysisPeripheral vascularRevascularisationRevascularization

Identifiers

PMID41689689
PMCPMC12906498

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.