Evidence map›Paper›PMID 41689618›Full record

Trial reportAIDS and behavior2026

Repeat Behavioral Counseling, With and Without Combination Nicotine Replacement Therapy, for Smoking Cessation Among People With HIV in South Africa.

Chukwudi Keke, Limakatso Lebina, Katlego Motlhaoleng, Raymond Niaura, David Abrams, Ebrahim Variava, Pattamukkil Abraham, Nikhil Gupte, Jonathan E Golub, Neil Martinson and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chukwudi KekeDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO, 80523, USA.
Limakatso LebinaAfrica Health Research Institute, Somkhele, Myeki, 3935, South Africa.
Katlego MotlhaolengPerinatal HIV Research Unit (PHRU), and Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa.
Raymond NiauraSchool of Global Public Health, New York University, New York, NY, 10003, USA.
David AbramsSchool of Global Public Health, New York University, New York, NY, 10003, USA.
Ebrahim VariavaPerinatal HIV Research Unit (PHRU), and Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa.
Pattamukkil AbrahamPerinatal HIV Research Unit (PHRU), and Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa.
Nikhil GupteDepartment of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Jonathan E GolubDepartment of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Neil MartinsonPerinatal HIV Research Unit (PHRU), and Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa.
Jessica L ElfDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO, 80523, USA. jessica.elf@colostate.edu.ORCID http://orcid.org/0000-0002-4298-6395

Funding

A Smoking Cessation Trial in HIV-infected patients in South AfricaR01DA030276 · NIDA · JOHNS HOPKINS UNIVERSITY · PI GOLUB, JONATHAN E. · 2011 to 2014
$2.0M
National Institute of Drug Abuse R01DA030276NIDA NIH HHS R01 DA030276
6 · The paper itself

Abstract

Repeating an intervention strategy consistent with the chronic disease care model has been demonstrated to be efficacious in improving cessation outcomes among smokers. However, evidence is lacking for repeat treatment outcomes among people with HIV (PWH) who smoke in low-resource settings. We evaluated outcomes among participants (n = 384) who were provided a second round of treatment after initial treatment failure in a randomized controlled trial of behavioral counseling (BC) with or without combination nicotine replacement therapy (nicotine patches and gum, cNRT). The primary outcome was self-reported smoking abstinence at 6 months after repeat treatment, biochemically verified using exhaled breath carbon monoxide (CO) and urine cotinine test. Secondary outcomes include smoking abstinence at 2 months after repeat treatment and smoking reduction, measured by changes in exhaled breath CO at 2 months and 6 months after repeat treatment. Overall, 35 (9%) participants were abstinent at 6 months post-repeat treatment, including 15 (8%) participants in the repeat BC group compared to 20 (11%) participants in the repeat BC + cNRT group. There was no significant difference in abstinence rates between repeat treatment groups (Chi Squared (χ

Indexed as

Behavior TherapyCounselingHIV InfectionsNicotine Replacement TherapySmokingSmoking CessationTobacco Use Cessation DevicesAdultBreath TestsCombined Modality TherapyFemaleHumansMaleMiddle AgedSouth AfricaTreatment OutcomeBehavioral counselingNicotine replacement therapyPeople with HIVRepeat treatmentSmoking cessationTobacco use

Identifiers

PMID41689618
PMCPMC13019438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.