Evidence map›Paper›PMID 41689585›Full record

ArticleHuman vaccines & immunotherapeutics2026

Influenza vaccine Hesitancy in older adults in China: A latent profile analysis.

Xian Chen, Sichen Xia, Zhu Zhu, Zhou Hui, Jinfeng Wu, Cuihua Sun, Chunxiu Zhou, Lihua Ceng

Abstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xian ChenOutpatient Department, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Hospital), Nanjing, PR China.
Sichen XiaStomatological College of Nanjing Medical University, Nanjing, PR China.
Zhu ZhuNursing Department, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Hospital), Nanjing, PR China.
Zhou HuiNursing Department, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Hospital), Nanjing, PR China.
Jinfeng WuJiangsu Nursing Association, Nanjing, PR China.
Cuihua SunJiangsu Nursing Association, Nanjing, PR China.
Chunxiu ZhouOutpatient Department, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Hospital), Nanjing, PR China.
Lihua CengNursing Department, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Hospital), Nanjing, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza vaccination coverage among older adults in China is low. We sought to identify latent vaccine-hesitancy profiles and their correlates. This community-based cross-sectional survey from May to July 2025 involved 1773 older adults from various areas in Jiangsu province. Data were collected via Wenjuanxing and included demographics, the Influenza Vaccine Hesitancy Scale, and the vaccine literacy scale. Group differences were examined using chi-square tests and one-way ANOVA; latent profile analysis (LPA) identified vaccine hesitancy subgroups, and multinomial logistic regression estimated correlates of profile membership. Three profiles emerged: Low Hesitancy (23.0%), Moderate Hesitancy (35.0%), and High Hesitancy (42.0%). Rural residence predicted Moderate (OR = 2.030) and High (OR = 2.993) hesitancy. Lower household income and chronic disease were associated with the Moderate Hesitancy profile, whereas male sex was associated with the High Hesitancy profile. Higher interactive (OR = 0.686) and critical (OR = 0.599) vaccine literacy were inversely associated with High hesitancy.Concerns about vaccine quality predicted both Moderate (OR = 1.433) and High (OR = 1.376) groups; knowledge gaps and fear of adverse reactions concentrated in the High group. Older adults show heterogeneous vaccine hesitancy phenotypes. Uptake efforts should move beyond one-size-fits-all messaging toward segmented strategies. These strategies should integrate cost-related measures with literacy-sensitive, trust-oriented communication, prioritizing rural residents, older men, and those with chronic conditions. The reported proportions of hesitancy profiles reflect our sample only and should not be viewed as nationally representative.

Indexed as

Influenza, HumanInfluenza VaccinesVaccination HesitancyAgedAged, 80 and overChinaCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedRural PopulationSurveys and QuestionnairesVaccinationInfluenza VaccinesChinaInfluenzalatent profile analysisolder adultsrisk perceptionvaccine hesitancyvaccine literacy

Identifiers

PMID41689585
PMCPMC12915807

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.