ArticleJournal of the American Chemical Society2026
The Catalytic Asymmetric Mukaiyama-Michael Reaction of Silyl Ketene Acetals with Cyclic Enones: Short Routes to Jasmonates.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Diastereoselective synthesis of substituted cyclopentanonesChemical science · 2026Article
- London Dispersion in Confined Chiral Ion-Pair Asymmetric Catalysis: From Background Interaction to Design Principle.Accounts of chemical research · 2026Article
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Authors and funding
9 authors.
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Abstract
A silylium imidodiphosphorimidate (IDPi) Lewis acid catalyst enables a broadly applicable organocatalytic asymmetric Mukaiyama-Michael addition of moderately electrophilic cycloenones with enol silanes, affording 1,4-adducts in up to 98% yield and >99:1 e.r. At 0.05 mol % catalyst loading, the reaction scales to 167 g of product with 96% catalyst recovery. The method accommodates a wide range of enones and silylated nucleophiles, allowing streamlined access to key jasmonates and related valuable targets. Computational studies elucidated the origin of the enantioselectivity in this reaction. This platform thus provides a versatile entry to structurally complex chiral scaffolds with direct relevance to plant signaling, fragrance chemistry, aromatherapy, and pharmaceutical sciences.
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Registered trials
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