Evidence map›Paper›PMID 41689416›Full record

Observational studyMycoses2026

Testing to Detect Candida auris Colonisation After Intrahospital Transfer From an Endemic Area, a Prospective Observational Study.

Laura Mezzogori, Martina Bavastro, Laura Magnasco, Federica Centorrino, Riccardo Schiavoni, Federica Portunato, Daniele Roberto Giacobbe, Antonio Vena, Vincenzo Di Pilato, Ramona Barbieri and 5 more

Abstract readObservational Study
In one paragraph

Observational study in Mycoses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Frontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laura MezzogoriDepartment of Health Sciences, University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0001-5873-0856
Martina BavastroDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Laura MagnascoInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Federica CentorrinoInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Riccardo SchiavoniDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Federica PortunatoInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Daniele Roberto GiacobbeDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Antonio VenaDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Vincenzo Di PilatoDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Ramona BarbieriIRCCS Ospedale Policlinico San Martino, Microbiology Unit, Genoa, Italy.
Andrea OrsiDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Giancarlo IcardiDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Anna MarcheseDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Matteo BassettiDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Malgorzata MikulskaDepartment of Health Sciences, University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0002-5535-4602

Funding

Gilead Sciences
6 · The paper itself

Abstract

backgroundCurrent international guidelines lack clear recommendations on the management of non-colonised patients undergoing intra-hospital transfer from the ward in which horizontal transmission of Candida auris is known to occur (defined as endemic for Candida auris) to wards with no horizontal transmission detected (defined as non-endemic wards), particularly regarding the timing and number of screening swabs needed to exclude colonisation.

methodsSingle-center prospective observational study at a tertiary-care hospital in Genoa, Italy, including adults transferred from the C. auris endemic-ICU (eICU) to non-endemic wards between January and December 2024. Patients who tested negative for C. auris colonisation both at eICU admission and at transfer, and who had ≥ 1 screening swab performed post-transfer, were included. Swabs (bilateral axilla/groin) were performed on Days 0-1, 2-3 after transfer, and then weekly, and tested for C. auris with real-time PCR. Patients were considered sufficiently screened to exclude colonisation if they underwent ≥ 2 swabs within the first 4 weeks after transfer.

resultsAmong 462 patients transferred from the eICU, 440 (95.2%) were non-colonised. Among them, 275 (62.5%) met inclusion criteria, and 208 (75.6%) were considered sufficiently screened. C. auris colonisation was detected in 34/208 (16.3%) patients, with 21 (61.8%) positive in the first post-transfer swab. Among 99 patients who had a negative result of a swab performed within 1 day before transfer, 7 (7.1%) resulted later positive. C. auris candidemia occurred in 4/34 (11.8%) patients with colonisation detected post-transfer, compared to 1/35 (2.9%) patients found colonised during eICU stay, and none occurred in non-colonised individuals.

conclusionsA single negative screening test at eICU discharge is insufficient to exclude colonisation, even if performed within 24 h from transfer. Repeated screening, ideally within the first 2 weeks post-transfer, is essential to detect colonisation and prevent further C. auris transmission.

Indexed as

Candida aurisCandidiasisCarrier StateCross InfectionPatient TransferAdultAgedCandidaFemaleHumansIntensive Care UnitsItalyMaleMiddle AgedProspective StudiesReal-Time Polymerase Chain ReactionCandida auriscandidemiacolonisationintensive care unitscreeningsurveillanceswabstransmission prevention

Identifiers

PMID41689416
PMCPMC12905662

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.