Evidence map›Paper›PMID 41689161›Full record

ArticleBiological research2026

Subthreshold Kir and I

Claudio Moreno, Denise Riquelme, Camila Cornejo, Paula Leyton, Elias Leiva-Salcedo

Abstract read
In one paragraph

Article in Biological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claudio MorenoDepartment of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile.
Denise RiquelmeDepartment of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile.
Camila CornejoDepartment of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile.
Paula LeytonDepartment of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile.
Elias Leiva-SalcedoDepartment of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile. elias.leiva@usach.cl.ORCID http://orcid.org/0000-0001-6487-5648

Funding

Agencia Nacional de Investigación y Desarrollo ANID-Subdirección de Capital Humano/Doctorado Nacional 21202294 2020Agencia Nacional de Investigación y Desarrollo ANID-Subdirección de Capital Humano/Doctorado Nacional 21231679 2023Agencia Nacional de Investigación y Desarrollo FONDECYT 1220680Universidad de Santiago de Chile, Vicerrectoria de Investigación, Innovación y creación Proyecto AYUDANTE_DICYT, Código 022543LS_Ayudante
6 · The paper itself

Abstract

Cortical layer 1 (L1) is a key site for integrating top-down and bottom-up information and is populated by inhibitory interneurons, including vasoactive intestinal peptide (VIP)-expressing cells. These interneurons regulate information flow across the cortical column by disinhibiting pyramidal neurons, yet the subthreshold ionic mechanisms that shape their excitability in the medial prefrontal cortex (mPFC) remain poorly understood. Here, we characterize the electrophysiological properties of L1b VIP interneurons in mouse mPFC, focusing on the role of the hyperpolarization-activated cation current (I

Indexed as

Hyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsPotassium Channels, Inwardly RectifyingPrefrontal CortexVasoactive Intestinal PeptideAction PotentialsAnimalsBarium CompoundsMaleMembrane PotentialsMicePatch-Clamp TechniquesPyrimidinesBarium CompoundsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsICI D2788Potassium Channels, Inwardly RectifyingPyrimidinesVasoactive Intestinal PeptideExcitabilityIhKirLayer 1Prefrontal cortexSubthreshold currentsVIP interneuron

Identifiers

PMID41689161
PMCPMC12988632

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.