Evidence map›Paper›PMID 41689101›Full record

ReviewJournal of translational medicine2026

Decoding adaptive immunity: advanced strategies in T and B cell repertoire analysis.

Xinjie Yu, Nan Peng, Wenjing Pan, Shenbo Xie, Congli Tang, Xue Wang, Hongna Liu, Yifei Shi, Yuqi He, Wanqing Wu and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xinjie Yu *Department of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Nan Peng *Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China.
Wenjing Pan *Department of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Shenbo XieInstitute of Child Health, University College London, London, UK.
Congli TangDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Xue WangDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Hongna LiuDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Yifei ShiHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China.
Yuqi HeDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Wanqing WuDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Daniel WeberiRepertoire Inc., Huntsville, AL, USA.
Libo NieHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, 412007, China.
Yuan LiuDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Zhu ChenDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Yan DengDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Miranda Byrne-SteeleiRepertoire Inc., Huntsville, AL, USA.
Zhe WangDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Wangzhe@tilcure.com.
Song LiDepartment of Clinical Laboratory of The First Affiliated Hospital, National Health Commission Key Laboratory of Birth Defect Research and Prevention, Ministry of Education Key Laboratory of Rare Pediatric Diseases, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Sosong1980@gmail.com.

Funding

Hunan Provincial Key Research and Development Program 2025JK2134Jiangsu Key R&D Projects No. BE2023679Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions No. 22A0385Natural Science Foundation of Hunan Province No. 2023JJ50199Noncommunicable Chronic Diseases National Science and Technology Major Project 2023ZD0507400, 2023ZD0507402
6 · The paper itself

Abstract

backgroundThe immune repertoire (IR) reflects the adaptive immune system of an organism by encompassing the diversity and composition of receptor sequences expressed by T and/or B lymphocytes. Despite significant advances in the efficiency and accuracy of antigen discrimination facilitated by high-throughput sequencing technologies, IR analysis remains challenging due to its extraordinary heterogeneity and the high dimensional nature of sequencing data. MAIN BODY: This review provides an overview of the key steps involved in IR profiling, highlighting factors that impact data accuracy, including sample sources, sequencing data quality control, repertoire characterization derived from the vast diversity of millions of receptors, and the specificity in lymphocyte-peptide interactions. Several bioinformatics pipelines have emerged to facilitate IR analysis, offering various computational tools to process and interpret complex datasets. Furthermore, we explore the integration of machine learning and multi-omics approaches, which are driving deeper insights into IR analysis.

conclusionsBy examining different perspectives, we summarize recent methodological and computational advancements in the field and provide unique insights into the evolving landscape of IR data analysis.

Indexed as

Adaptive ImmunityB-LymphocytesT-LymphocytesAnimalsComputational BiologyHigh-Throughput Nucleotide SequencingHumansImmunoinformaticsBioinformaticsHigh-throughput sequencingImmune repertoireMachine learningMulti-omics analysis

Identifiers

PMID41689101
PMCPMC13005323

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.