ArticleStem cell research & therapy2026
Nonthermal radiofrequency radiation promotes hematopoietic stem and progenitor cells function by regulating Ca
Article in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHematopoietic stem and progenitor cells (HSPCs) are crucial for blood production and regeneration. While their function is known to be regulated by diverse physical cues, the impact of pervasive radiofrequency electromagnetic fields (RF-EMF), particularly through non-thermal radiofrequency radiation (RFR) mechanisms, remains poorly understood.
methodsWe conducted colony-forming unit (CFU) assay in vitro and competitive transplantation assay in vivo to evaluate whether RFR influences hematopoiesis reconstitution capacity. Subsequently, the effects of RFR preconditioning on hematopoietic injury induced by ionizing radiation in mice were assessed by continuously monitoring the peripheral blood, HSPCs number, and colony-forming units. The influence of RFR on radioprotection unit frequency was evaluated using multiple gradients, non-competitive mouse transplantation models. Seahorse XF assays were employed to characterize cellular energy metabolic status, while specific fluorescent probes were utilized to detect calcium ion (Ca
resultsNon-thermal 2856 MHz RFR enhanced HSPCs colony formation activity and reconstitution capacity, without compromising the multilineage differentiation homeostasis. RFR preconditioning accelerated hematopoietic recovery following ionizing radiation and increased radioprotection unit frequency. Mechanistically, RFR increased plasma membrane fluidity which potentiates PMCA activity, resulting in elevated Ca
conclusionOur results provided the first evidence that non-thermal RFR can improve HSPCs function. The central mechanism involved RFR-induced plasma membrane fluidity, activation of PMCA, thus accelerating Ca
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