Trial reportBMC musculoskeletal disorders2026
The relationship between neck and body awareness, pain, and proprioception with central sensitization in patients with chronic nonspecific neck pain.
Trial report in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06976398 (Investigation of Central Sensitisation in Patients With Chronic Non-spesific Neck Pain), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Central Sensitisation in Patients With Chronic Non-spesific Neck Pain
Who cites it
3 citing papers in PubMed.
- Exercise Participation and Clinical Characteristics of Desk-Based Workers with Chronic Non-Specific Neck Pain Exposed to Increased Ergonomic Risk: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.Pain and therapy · 2026Review
- Multidimensional Analysis of Physical, Psychosocial, and Cognitive Impairment in People with Chronic Neck Pain.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundCentral sensitization (CS) is a significant cause of chronic pain, causing increased sensitivity at the central nervous system level. However, the effects of CS in patients with chronic nonspecific neck pain (CNSNP) are poorly understood. This study aimed to compare pain severity, pressure pain threshold, disability, proprioception, neck and body awareness in patients with CNSNP with and without CS, and to investigate the relationship between them.
methodsEighty-three patients were included in this cross-sectional study and were divided into two groups, CS and non-CS, according to the Central Sensitization Inventory (CSI). Pain severity (Numeric Pain Rating Scale (NPRS)), pressure pain threshold (PPT), neck disability (Neck Disability Index (NDI)), proprioception (Cervical range of motion device (CROM)), and neck (Fremantle Neck Awareness Questionnaire (FreNAQ)) and body awareness (Body Awareness Questionnaire (BAQ)) were measured. Data analysis was performed using an Independent Samples T-test and the Mann-Whitney U test. Spearman correlation coefficients and multivariate logistic regression were applied to analyze potential predictors of having CS.
resultsThe NPRS, NDI, flexion and extension joint position error, FreNaQ, and BAQ scores of the CNSNP with the CS group were statistically significantly higher than those of the non-CS group (p < 0.05), and the PPT value was lower (p = 0.013). Increased pain intensity (OR = 1.722, p = 0.005) and neck extension joint position error (OR = 1.517, p = 0.006) significantly increased the likelihood of CS (p < 0.001).
conclusionPatients with CNSNP who had CS had increased pain intensity and functional disability, decreased pressure pain threshold, and worsened proprioceptive sensory feedback, neck, and body awareness. These results suggest that CS may be associated with worsening symptoms. Therefore, CS should not be overlooked in the clinical follow-up of patients with CNSNP. Submitted to ClinicalTrials (number: NCT06976398, date: 05/02/2025).
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