Observational studyBMC geriatrics2026
Impact of a history of falls on clinical outcomes in older adult non-valvular atrial fibrillation patients: an ANAFIE registry study.
Observational study in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Navigating Anticoagulation Decisions in Atrial Fibrillation and Frailty Comorbidity.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA history of falls represents frailty in older adult patients. However, the influence of a history of falls on clinical outcomes in older adult non-valvular atrial fibrillation (NVAF) patients has not been fully elucidated. This All Nippon AF In the Elderly (ANAFIE) Registry sub-analysis evaluated the relationship between a history of falls within the year prior to the study's commencement and 2-year clinical outcomes in a large, older adult (aged ≥ 75 years) Japanese population with NVAF.
methodsThe ANAFIE Registry (UMIN000024006) was a multicenter, prospective, observational study with a 24-month follow-up period. Of the 32,275 enrolled patients, 28,664 with available fall history data were divided into two groups: those with and without a history of falls within the previous year (n = 2,347 and 26,317, respectively).
resultsAnticoagulant therapy was administered in 95% and 94% of these patients, respectively. Compared with patients without a history of falls, those with a fall history had higher incidences of stroke/systemic embolic events (2.59 vs. 1.52 per 100 person-years), major bleeding (2.20 vs. 0.96), intracranial hemorrhage (ICH) (1.71 vs. 0.66), cardiovascular death (2.12 vs. 0.97), all-cause death (6.78 vs. 3.34), and falls/fractures (13.52 vs. 5.44) (all, P < 0.001) during the follow-up period. In multivariable models, these associations remained significant for all outcomes. Notably, these clinical events, particularly major bleeding and ICH, were frequently observed after falls/fractures that occurred during the follow-up period. Compared with warfarin, direct oral anticoagulants were associated with significantly lower risks of new falls/fractures during the follow-up period, irrespective of baseline fall history.
conclusionsA history of falls within the previous year was associated with worse prognosis in older adult Japanese NVAF patients. Major bleeding (particularly ICH) occurred frequently following new occurrences of falls/fractures. Warfarin was associated with higher risks of subsequent falls/fractures.
trial registrationANAFIE Registry was registered in the UMIN Clinical Trials Registry (identifier: UMIN000024006) on September 12, 2016.
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