ArticleBiological procedures online2026
Leishmania Infection: A Bioorganic Model Under the Light of Benchtop Low Field Nuclear Magnetic Resonance.
Article in Biological procedures online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-field benchtop Nuclear Magnetic Resonance (NMR) spectrometers rely on permanent magnets and do not require deuterated solvents, being increasingly employed for quality control and the profilometric assays of complex matrices from food products to metabolically enriched exudates. In this study, the non-destructive, non-invasive, low-cost and time-effective nature of benchtop NMR investigations was exploited to separate Leishmania infantum -positive and -negative dog (Canis lupus familiaris) sera. Moreover, among the Leishmania-positive samples, sera with either circulating free or complexed antibody molecules displayed distinctive NMR profiles with promising discriminatory potential.
methodsThis approach is made possible by the identification of specific bioorganic 1D and 2D NMR signals, such as protons found in pyranose (PYR), phospholipid (SPC), and acetyl moieties (Glyc), whose distribution in serum samples varies in association with specific parasitic infections.
resultsThe discrimination among Leishmania Negative (n=5) vs Low positive (n=8) samples was successfully performed using the summed integration areas of 3 main buckets (SPC, Glyc, late PYR), while the analytical speciation of High (Ab+) positive (n=8) samples was reached recurring to a further integrated area, belonging to early PYR signals.
conclusionThe characterization of inflammatory states through traces of oxidized lipids, and the study of immunological activation using bioorganic signals of glycoproteins, can be easily exploited on a broad scale even in different pathological contexts with features similar to the Leishmania case report.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.