Evidence map›Paper›PMID 41688850›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Glypican-3-targeted immunoPET imaging of hepatocellular carcinoma: a translational study.

Zhaoguo Lin, Wenzhu Hu, Mengting Li, Zhidi Pan, Yuan Feng, Xiao Zhang, Biao Yang, Yongkang Gai, Dawei Jiang, Jianwei Zhu and 2 more

Registry-linked trialAbstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06383520 (Study on the Clinical Application Value of PET Imaging Targeting GPC3 in Hepatocellular Carcinoma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06383520 early_phase1recruitingnot on this map

Study on the Clinical Application Value of PET Imaging Targeting GPC3 in Hepatocellular Carcinoma

TypeinterventionalSponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRan2023 to 2025Enrolled100ConditionsMalignant Neoplasm of LiverArms68Ga-aGPC3-scFv/Fab
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhaoguo Lin *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Wenzhu Hu *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Mengting LiDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Zhidi PanKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Yuan FengDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Xiao ZhangDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Biao YangDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Yongkang GaiDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Dawei JiangDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China.
Jianwei ZhuJecho Institute, Shanghai, 200240, China.
Xiong CaiDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. caixiong@hust.edu.cn.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, Hubei Province, 430022, China. lxl730724@hotmail.com.

Funding

Hubei Science and Technology Innovation Talent Program 2023DJC162Innovative Drug Research and Development-National Science and Technology Major Project 2025ZD1803400National Key Research and Development Program of China 2022YFB3808200National Natural Science Foundation of China 22277031National Natural Science Foundation of China 82030052National Natural Science Foundation of China 82202233Natural Science Foundation of Hubei Province 2022CFB227Science and Technology Program of Hubei Province 2025BCB006
6 · The paper itself

Abstract

purposeAccurate diagnosis of hepatocellular carcinoma (HCC) remains a clinical challenge. Glypican-3 (GPC3) is highly expressed in HCC but not in normal liver tissue, making it a promising target for PET-based molecular imaging, which may complement existing approaches for HCC diagnosis. In this study, we developed a new GPC3-targeted immunoPET radiotracer for noninvasive visualization of GPC3 expression and conducted a first-in-human, proof-of-concept evaluation in patients with HCC to assess its clinical feasibility.

methodsAn anti-GPC3 antigen-binding fragment (Fab) was generated under Good Manufacturing Practice conditions and labeled with Gallium-68 (

results[

conclusion[ CLINICAL

trial registrationClinicalTrials.gov, NCT06383520. Registered on April 25, 2024 ( https://clinicaltrials.gov/study/NCT06383520 ).

Indexed as

Carcinoma, HepatocellularGlypicansLiver NeoplasmsPositron Emission Tomography Computed TomographyAgedAnimalsCell Line, TumorFemaleGallium RadioisotopesHumansMaleMiceMiddle AgedTissue DistributionTranslational Research, BiomedicalGallium-68Gallium RadioisotopesGlypicansGPC3 protein, humanAntigen-binding fragmentGlypican-3Hepatocellular carcinomaImmuno-positron emission tomographyNuclear medicine

Identifiers

PMID41688850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.