ArticleNature aging2026
Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.
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Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
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Who cites it
5 citing papers in PubMed.
- Speech clocks decode dementia phenotypes, social exposome, and biological aging.Science advances · 2026Article
- Generalizability of EEG-Based DEMENTIA Classifiers: A Multicenter study of Alzheimer's, MCI, and FTD.medRxiv : the preprint server for health sciences · 2026Article
- Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A harmonized framework for studying exceptional cognitive aging in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
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Authors and funding
64 authors.
Ariel Caviedes *Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Felipe Cabral-Miranda *Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Paulina OrellanaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Hernán HernándezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Fernando HenríquezGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Raul Gonzalez-GomezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.ORCID http://orcid.org/0000-0003-2341-011X
Matias PizarroLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Joaquin MigeotLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Carolina Ochoa-RosalesLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Carolina Gonzalez-SilvaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Nickole Marin-DiazLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Carlos Coronel-OliverosLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Hernando Santamaría-GarcíaGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Danilo CarmonaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Adolfo M GarcíaGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6936-0114
Andrea SlachevskyGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Andrew SingletonCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Andy Yue QiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1914-8710
Brian LawlorGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Bruce MillerGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Catherine DhoogeLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Caroline PantazisCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Chinedu T Udeh-MomohSchool of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
David AguillónGrupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.ORCID http://orcid.org/0000-0003-2283-536X
Diana L MatallanaInstituto de Genética Humana. Facultad de Medicina. Pontificia Universidad Javeriana, Bogotá, Colombia.
Eduardo R ZimmerDepartment of Pharmacology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-5349-0053
Elisa de Paula França ResendeGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Francesca R FarinaGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4410-4368
Francisca CabelloLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Francisco LoperaGrupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.ORCID http://orcid.org/0000-0003-3986-1484
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0003-3930-4354
José Alberto Avila-FunesDirección de Enseñanza. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Juliana Acosta-UribeGrupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Katherine L PossinGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Kenneth S KosikGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3224-5179
Kun HuMedical Biodynamics Center, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0350-3132
Leonel T TakadaHospital das Clínicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Maira Okada de OliveiraGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Marcelo Adrian MaitoLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Marc Suárez-CalvetBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2993-569X
Maria E GodoyLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Maria Isabel BehrensDepartamento de Neurología y Psiquiatría, Clínica Semana-Universidad del Desarrollo, Santiago, Chile.ORCID http://orcid.org/0000-0003-0964-426X
Mario A ParraSchool of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.
Marta Del CampoBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2808-3699
Martin BrunoInstitute of Biomedical Sciences (ICBM), Universidad Católica de Cuyo, San Juan, Argentina.
Nancy GelvezInstituto de Genética Humana. Facultad de Medicina. Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID http://orcid.org/0000-0002-3925-1451
Natalia Pozo-CastroGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.ORCID http://orcid.org/0000-0002-9852-5504
Nilton CustodioUnidad de diagnóstico de deterioro cognitivo y prevención de demencia, Instituto Peruano de Neurociencias, Lima, Perú.ORCID http://orcid.org/0000-0002-8025-3272
Rodrigo OrtegaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.ORCID http://orcid.org/0000-0001-9643-2091
Rodrigo SantibanezNeurology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-2391-4468
Rolando de la CruzFaculty of Engineering and Sciences, Universidad Adolfo Ibáñez, Santiago, Chile.
Rosa MontesinosUnidad de diagnóstico de deterioro cognitivo y prevención de demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Sarah McDonaghGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0056-1361
Shireen JavandelGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.
Sonia M D BruckiCognitive and Behavioral Neurology Unit, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Stefanie D Pina-EscuderoGlobal Brain Health Institute (GBHI), University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7467-8365
Victor ValcourMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Ziyi LiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jennifer S YokoyamaMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7274-2634
Agustin IbañezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile. agustin.ibanez@gbhi.org.ORCID http://orcid.org/0000-0001-6758-5101
Claudia Duran-AniotzLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile. claudia.duran@uai.cl.
Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)
Funding
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MCircadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0MNIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG083799
Abstract
Dementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and environmental heterogeneity, is particularly underrepresented in biomarker research. Here we show that plasma AT(N) biomarkers can distinguish Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) in a multinational Latin American cohort (N = 605). Aβ
Indexed as
Alzheimer DiseaseFrontotemporal Lobar DegenerationNeurofilament Proteinstau ProteinsAgedAmyloid beta-PeptidesBiomarkersFemaleHumansLatin AmericaMaleMiddle AgedPeptide FragmentsROC CurveAmyloid beta-PeptidesBiomarkersneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau Proteins
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