Evidence map›Paper›PMID 41688785›Full record

ArticleActa pharmacologica Sinica2026

MPTP and rotenone cause dopaminergic neuronal death by increasing DDIT4 promoter lactylation.

Jing-Chao Hong, Yu-Shu Yang, Si-Han He, Juan-Juan Huang, Xin-Rui Zhang, Fang-Fang Zeng, Jie-Qiong Tan, Hai-Long Han, Zhuo-Hua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing-Chao HongInstitute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province, Central South University, Changsha, 410008, China.
Yu-Shu YangInstitute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province, Central South University, Changsha, 410008, China.
Si-Han HeInstitute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province, Central South University, Changsha, 410008, China.
Juan-Juan HuangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xin-Rui ZhangInstitute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province, Central South University, Changsha, 410008, China.
Fang-Fang ZengInstitute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province, Central South University, Changsha, 410008, China.
Jie-Qiong TanCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410008, China.
Hai-Long HanDepartment of Neurosciences, Hengyang Medical College, University of South China, Hengyang, 421001, China.
Zhuo-Hua ZhangInstitute of Molecular Precision Medicine, Xiangya Hospital, Key Laboratory of Molecular Precision Medicine of Hunan Province, Central South University, Changsha, 410008, China. zhangzhuohua@sklmg.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental toxicants such as MPTP and rotenone induce Parkinsonism in both humans and animals. Lactate-driven histone lactylation has recently been implicated in microglial activation and broader CNS pathology. However, its role in dopaminergic (DA) neurons and Parkinson's disease (PD)-related toxicant responses remains unclear. In this study, we investigated whether neurotoxicant-induced histone lactylation contributes to PD pathogenesis. SH-SY5Y cells were exposed to MPP

Indexed as

Dopaminergic NeuronsRotenoneTranscription Factors1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsCell DeathCell Line, TumorHistonesHumansLactic AcidMaleMiceMice, Inbred C57BLParkinsonian DisordersPromoter Regions, Genetic1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineDDIT4 protein, humanHistonesLactic AcidRotenoneTranscription FactorsDDIT4histone lactylationMPTPParkinson’s diseaserotenonesodium dichloroacetate

Identifiers

PMID41688785
PMCPMC13197455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.