ArticleCommunications biology2026
Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Hospital-treated infection associated with Alzheimer's disease pathology: underlying mechanisms.Molecular psychiatry · 2026Review
- The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Barbados aloe as a water-administered therapeutic against Pseudomonas aeruginosa infection in Clarias gariepinus: Effects on hemato-biochemical profiles, electrolyte homeostasis, antioxidant capacity, and tissue histology.Veterinary research communications · 2026Article
- Barrier breakdown: lung-brain crosstalk in systemic inflammation.Journal of neuroinflammation · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Many patients suffer from incident dementia after lung infections. Previous studies demonstrated that cytotoxic tau is released from the lungs in response to bacterial pneumonia, causing cognitive deficits and tau seeding. We aimed to determine the impact pneumonia has on blood-brain barrier (BBB) permeability, glial activation, and tau phosphorylation in the brain following infection and the involvement of tau. We found that lung infection with Pseudomonas aeruginosa (P. aeruginosa) increased BBB permeability, astrocyte activation, and phosphorylated tau (ptau) levels in the brain 24-hours (h) post-infection in C57BL/6J mice. Conversely, tau knockout (KO) mice had no BBB injury or glial activation 24 h after infection. Additionally, we found increased levels of several kinases and proinflammatory cytokines with infection in C57BL/6J and tau KO mice. Thus, tau is necessary for pneumonia-induced BBB dysfunction and astrocyte reactivity in the brain and may be an innate immune response link between infection and dementia.
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Registered trials
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