Evidence map›Paper›PMID 41688663›Full record

ArticleCommunications biology2026

Surface decoration of bacteria generates robust living therapeutics for improved ulcerative colitis therapy.

Junyu Liu, Zhihao Fang, Xiaobin Li, Xiaopeng Zhang, Yun Chen, Fujia Kou, Long Huang, Huanxian Yang, Yilin Zheng, Yuqing Huang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Junyu Liu *Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Zhihao Fang *School of Chemistry and Chemical Engineering, State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China.
Xiaobin Li *Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Xiaopeng ZhangInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Yun ChenInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Fujia KouInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Long HuangDepartment of Chemical Engineering, Tsinghua University, Beijing, China.
Huanxian YangSchool of Chemistry and Chemical Engineering, State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China.
Yilin ZhengInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Yuqing HuangInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Yi WangDepartment of Chemical Engineering, Tsinghua University, Beijing, China.
Xueqing QiuSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Jun GeDepartment of Chemical Engineering, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-5503-8899
Yong QianSchool of Chemistry and Chemical Engineering, State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China. ceyqian@scut.edu.cn.ORCID http://orcid.org/0009-0009-5654-8562
Xin-Hui XingInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China. xhxing@mail.tsinghua.edu.cn.
Can Yang ZhangInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China. zhang.cy@sz.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-6975-5781

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22278242
6 · The paper itself

Abstract

Oral probiotics have shown great potential in treating ulcerative colitis (UC). However, gastrointestinal obstacles substantially inactivate probiotics, impeding delivery and colonization in the colon. Here, we developed robust oral living therapeutics with high colon-accumulating effect via surface decoration of probiotic (Escherichia coli Nissle 1917, EcN) using a layer-by-layer approach. Calcium ions and carboxymethyl-modified lignin (CML) were sequentially coated on EcN to generate an acid-resistant and colitis microenvironment-responsive system (CML@EcN). After oral administration in a male C57BL/6 N mouse model, EcN were specifically delivered to the site of colitis and successfully colonized. The CML@EcN notably alleviated colitis by modulating immune dysfunction, reshaping gut microbiota (GM), and repairing the intestinal barrier. The delivery mechanism was explored based on experiments and mathematical models. Interestingly, this engineering approach can be further used to decorate other bacteria. Consequently, the robust CML@EcN shows high colon-targeting delivery efficacy and great potential in UC therapy.

Indexed as

Colitis, UlcerativeEscherichia coliProbioticsAdministration, OralAnimalsColonDisease Models, AnimalGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BL

Identifiers

PMID41688663
PMCPMC13013703

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.