ArticleScientific reports2026
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Mapping the MicroRNA Landscape of Cadmium Exposure: A Bibliometric and Bioinformatics Analysis of Molecular Targets and Regulatory Pathways.International journal of molecular sciences · 2026Review
- Article
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Authors and funding
9 authors.
Funding
Abstract
To date, no effective chelation therapy exists to remove cadmium (Cd) from the kidneys, a condition that increases the risk of cadmium-induced chronic kidney disease among humans. consequently, it is vital to prevent kidney damage due to cadmium exposure. However, it has been challenging to identify an early diagnostic marker of cadmium-induced kidney damage through mechanism studies. Interestingly, our previous study revealed that the expression of the microRNA miR-363-3p was upregulated in workers who had been diagnosed with chronic occupational cadmium toxicity. Thus, we aimed to investigate the role of miR-363-3p and its potential signaling pathway in cadmium-induced kidney damage. In this study, we identified a novel signaling pathway, hsa_circ_0075684/miR-363-3p/Krüppel-Like Factor 4 (KLF4), through a comprehensive bioinformatics analysis involving six databases. Next, we validated the role of the hsa_circ_0075684/miR-363-3p/KLF4 pathway in human renal tubular epithelial cell line (HK-2) treated with 0, 5, 10 and 15 µM cadmium chloride (CdCl
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