ArticleNature genetics2026
Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation.
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Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026Review
- Gut microbiome composition and functional potential associate with incident type 2 diabetes in 4,685 adults from a Swedish prospective cohort.Cell reports. Medicine · 2026Article
- Gut Microbiota Metabolic Reprogramming Drives Endocrine and Immune Resistance in Hormone-Dependent Cancers.Cancers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Koen F Dekkers *Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-4074-7235
Kamalita Pertiwi *Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2861-9051
Gabriel Baldanzi *Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3962-3953
Per LundmarkDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0009-0006-2334-8802
Ulf HammarDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Marta Riise MoksnesDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-2690-5153
Eivind CowardDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0009-0008-1323-3555
Maria NethanderDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0003-3688-906X
Ghassan Ali SalihDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0009-0003-5938-8222
Mariam MiariDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Diem NguyenDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-9680-5772
Sergi Sayols-BaixerasDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Aron C EklundCmbio, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0861-1001
Jacob Bak HolmCmbio, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1756-0875
H Bjørn NielsenCmbio, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2281-5713
Camila Gazolla VolpianoCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Guillaume MéricDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-6288-9958
Manonanthini ThangamDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-7164-6525
Liisa HakasteFolkhälsan Research Center, Helsinki, Finland.
Tiinamaija TuomiDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Emma AhlqvistDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-6513-2384
Christopher A SmithInstitute of Metabolic Science-Metabolic Research Laboratories & MRC-Metabolic Diseases Unit, University of Cambridge, Cambridge, UK.
Marie AllenDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Frank ReimannInstitute of Metabolic Science-Metabolic Research Laboratories & MRC-Metabolic Diseases Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9399-6377
Fiona M GribbleInstitute of Metabolic Science-Metabolic Research Laboratories & MRC-Metabolic Diseases Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4232-2898
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9633-2805
Kristian HveemDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.
Olle MelanderDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Peter M NilssonDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-5652-8459
Gunnar EngströmDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
J Gustav SmithThe Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Science for Life Laboratory, Gothenburg, Sweden.
Karl MichaëlssonDepartment of Surgical Sciences, Medical Epidemiology, Uppsala University, Uppsala, Sweden.
Johan ÄrnlövDepartment of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Huddinge, Sweden.
Marju Orho-MelanderDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-3578-2503
Tove FallDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. tove.fall@medsci.uu.se.ORCID http://orcid.org/0000-0003-2071-5866
Funding
Centrum fÖr Klinisk Forskning Dalarna (Center for Clinical Research Dalarna) CKFUU-1025348, 987986, 976460, 963488, 936407, 695401, and 797891Department of Health | National Health and Medical Research Council (NHMRC) GNT2013468Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 2018-0343Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 20200173Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 2020-0711Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 2022-0344Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 2023-0687Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) KAW 2015.0317Lars Erik Lundbergs Stiftelse för Forskning och Utbildning (Lundberg Foundation for Research and Education) LU2021-0096Novo Nordisk Fonden (Novo Nordisk Foundation) 190C0055250 and 22OC0078421RCUK | Medical Research Council (MRC) MRC_MC_UU_12012/3Vetenskapsrådet (Swedish Research Council) 2018-02784, 2018-02837, EXODIAB 2009-1039Vetenskapsrådet (Swedish Research Council) 2019-01015, 2020-00243Vetenskapsrådet (Swedish Research Council) 2019-01236Vetenskapsrådet (Swedish Research Council) 2019-01291Vetenskapsrådet (Swedish Research Council) 2019-01471Vetenskapsrådet (Swedish Research Council) 2020-01392Vetenskapsrådet (Swedish Research Council) 2020-02191Vetenskapsrådet (Swedish Research Council) 2021-02273Vetenskapsrådet (Swedish Research Council) 521-2013-2756Wellcome Trust (Wellcome) 220271/Z/20/Z
Abstract
Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1-OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness. We further identified 15 study-wide significant genetic associations (P < 5.4 × 10
Indexed as
Gastrointestinal MicrobiomeIntestinal MucosaMetagenomeReceptors, G-Protein-CoupledAdolescentAdultAgedAged, 80 and overBile Acids and SaltsCellular MicroenvironmentFatty AcidsFemaleGenome-Wide Association StudyHumansMaleMetagenomicsBile Acids and SaltsFatty AcidsOR51E1 protein, humanReceptors, G-Protein-CoupledSLC5A11 protein, humanSodium-Glucose Transport Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.