Evidence map›Paper›PMID 41688544›Full record

ArticleScientific reports2026

Fish (Alaska Pollock) protein intake attenuates age-related short-term memory decline through gut microbiota modulation.

Yuki Murakami, Ryota Hosomi, Genki Tanaka, Hirokazu Murakami, Ayaka Kanto, Takahiro Kimura, Yukio Imamura, Munehiro Yoshida, Kenji Fukunaga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuki MurakamiDepartment of Hygiene and Public Health, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, 573-1010, Osaka, Japan. murakami.yk@kmu.ac.jp.
Ryota HosomiFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan. hryotan@kansai-u.ac.jp.
Genki TanakaFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan.
Hirokazu MurakamiFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan.
Ayaka KantoFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan.
Takahiro KimuraFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan.
Yukio ImamuraDepartment of Hygiene and Public Health, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, 573-1010, Osaka, Japan.
Munehiro YoshidaFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan.
Kenji FukunagaFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, 564-8680, Osaka, Japan.

Funding

Japan Society for the Promotion of Science 20K21587
6 · The paper itself

Abstract

Dysbiosis leads to decreased intestinal barrier function, causing systemic inflammation and possibly the development of age-related cognitive decline. In this study, we investigated the effect of an Alaska pollack protein (APP) diet on cognitive function, gut microbiota composition, intestinal barrier function, and neuroinflammation in senescence-accelerated mouse prone8 (SAMP8) and senescence-resistant AKR/J (SAMR1) mice. The APP diet produced significant improvements across multiple parameters. It enhanced glucose tolerance in both strains and prevented short-term memory decline in SAMP8 mice. Microbiome analysis revealed that APP intake promoted beneficial bacteria growth, specifically increasing Lactobacillus in SAMR1 and butyrate-producing Lachnospiraceae in SAMP8. Notably, while APP diet increased butyrate-producing bacteria in SAMP8, short-chain fatty acids (SCFAs) analysis showed increased aetate but unchanged butyrate levels, suggesting complex metabolic interactions beyond simple bacterial abundance. Moreover, the APP diet significantly suppressed neuroinflammation in SAMP8, evidenced by decreased proinflammatory cytokine expression, microglia and astrocyte activation, and attenuated demyelination in the hippocampus. These findings suggest that APP intake prevents age-related short-term memory decline through beneficial gut microbiota modulation, and reduced neuroinflammation, supporting the role of the gut-brain axis in cognitive aging.

Indexed as

AgingDietary ProteinsGastrointestinal MicrobiomeMemory, Short-TermAnimalsFishesIntestinal Barrier FunctionMaleMiceDietary ProteinsCognitive declineDementiaDietFish proteinGut-brain axisGut microbiotaPrevention

Identifiers

PMID41688544
PMCPMC12976315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.