Evidence map›Paper›PMID 41688445›Full record

ArticleNature communications2026

The interplay of sleep characteristics with health factors and gut microbiome.

Jiafei Wu, Sergio Andreu-Sánchez, Haoran Peng, Ranko Gacesa, Milla Brandão Gois, Siobhan Brushett, Rinse Weersma, Daoming Wang, Alexander Kurilshikov, Alexandra Zhernakova and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiafei WuDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-7774-3473
Sergio Andreu-SánchezDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Haoran PengDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0009-0002-7779-7073
Ranko GacesaDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-2119-0539
Milla Brandão GoisDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-7918-2481
Siobhan BrushettDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-5445-2972
Rinse WeersmaDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-7928-7371
Daoming WangDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-4623-8527
Alexander KurilshikovDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Alexandra ZhernakovaDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Jingyuan FuDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands. j.fu@umcg.nl.ORCID http://orcid.org/0000-0001-5578-1236
Daria V ZhernakovaDepartment of Genetics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands. dashazhernakova@gmail.com.ORCID http://orcid.org/0000-0001-6531-3890

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests a bidirectional relationship between sleep and the gut microbiome. In this study, we explore the associations of sleep characteristics with lifestyle factors and gut microbiome composition in 6941 participants from the Lifelines Dutch Microbiome Project. We show that lower alpha diversity is associated with poorer sleep quality, later chronotype, and greater social jet lag, while beta diversity is linked to both sleep quality and social jet lag. Of the 137 bacterial species associated with sleep, 35.6% are validated in an independent cohort. Mediation analyses indicate that, while changes in species abundance are largely a consequence of sleep behavior, certain species may mediate diet's influence on sleep. For example, we find that Clostridia species UC5_1_1E11 and SGB14844 mediate the effect of coffee intake on social jet lag. These findings highlight the intricate relationship between diet, the gut microbiome, and sleep, suggesting the potential for microbiome-targeted interventions to improve sleep health.

Indexed as

ChronotypeGastrointestinal MicrobiomeSleepAdultClostridiumCoffeeDietEuropean PeopleFemaleHumansMaleMiddle AgedCoffee

Identifiers

PMID41688445
PMCPMC13013938

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.