Evidence map›Paper›PMID 41688236›Full record

ArticleThe Science of the total environment2026

Prenatal exposure to extreme heat and autism in children.

David G Luglio, Xin Yu, Jane C Lin, Ting Chow, Mayra P Martinez, Zhanghua Chen, Sandrah P Eckel, Joel Schwartz, Frederick W Lurmann, Nathan Pavlovic and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David G LuglioDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70118, USA.
Xin YuDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Jane C LinDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 91101, USA.
Ting ChowDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 91101, USA.
Mayra P MartinezDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 91101, USA.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Frederick W LurmannSonoma Technology, Inc., Petaluma, CA, 94954, USA.
Nathan PavlovicSonoma Technology, Inc., Petaluma, CA, 94954, USA.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 91101, USA. Electronic address: anny.h.xiang@kp.org.
Md Mostafijur RahmanDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70118, USA. Electronic address: mrahman8@tulane.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Translation CoreP2CES033433 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jill E Johnston · 2022 to 2026
$4.9M
The role of vulnerability and adaptation on the effects of co-occurring heat, air pollution, and wildfire on heart failure hospitalizationsP20HL176204 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HABRE, RIMA · 2024 to 2024
$4.1M
The Impact of Air Pollution Exposure on COVID-19 Severity and MortalityR01ES029963 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI MCCONNELL, ROB S, XIANG, ANNY H · 2019 to 2022
$3.3M
Effects of air pollution and gestational diabetes on autismR56ES028121 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI XIANG, ANNY H · 2017 to 2017
$250k
NHLBI NIH HHS P20 HL176204NIEHS NIH HHS P2C ES033433NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES029963NIEHS NIH HHS R56 ES028121
6 · The paper itself

Abstract

Increasing global temperatures have been associated with neural tube defects and neurodevelopmental delays. Effects of gestational temperature exposures on autism, another neurodevelopmental outcome with prenatal risk factors, have not been previously investigated. This study examined associations of weekly maximum and minimum temperature (T

Indexed as

Autistic DisorderExtreme HeatMaternal ExposurePrenatal Exposure Delayed EffectsCaliforniaChild, PreschoolFemaleHumansMalePregnancyRetrospective StudiesASDAutismHeatPrenatalSensitive windowsTemperature

Identifiers

PMID41688236
PMCPMC12991822

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.