Evidence map›Paper›PMID 41688052›Full record

ArticleACS synthetic biology2026

Continuous Directed Evolution of a Short-Lived Plant Histidinol Dehydrogenase.

Edmar R Oliveira-Filho, Anuran K Gayen, Bryan J Leong, Katharina Belt, Cătălin Voiniciuc, A Harvey Millar, Andrew D Hanson

Abstract read
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edmar R Oliveira-FilhoHorticultural Sciences Department, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0002-1597-0830
Anuran K GayenHorticultural Sciences Department, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0003-0231-417X
Bryan J LeongHorticultural Sciences Department, University of Florida, Gainesville, Florida 32611, United States.
Katharina BeltARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Crawley, 6009 WA, Australia.
Cătălin VoiniciucHorticultural Sciences Department, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0001-9105-014X
A Harvey MillarARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Crawley, 6009 WA, Australia.ORCID 0000-0001-9679-1473
Andrew D HansonHorticultural Sciences Department, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0003-2585-9340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enzyme protein turnover accounts for about half the maintenance energy budget in plants. Slowing turnover─i.e., extending the effective working life (Catalytic Cycles till Replacement, CCR)─of short-lived enzymes is thus a rational strategy to conserve energy and carbon and raise crop productivity.

Indexed as

Alcohol OxidoreductasesArabidopsisArabidopsis ProteinsDirected Molecular EvolutionHistamineHistidineMutationSaccharomyces cerevisiaeAlcohol OxidoreductasesArabidopsis ProteinsHistamineHistidinedirected evolutionenzyme performancehistidinol dehydrogenaseprotein turnover

Identifiers

PMID41688052
PMCPMC13010363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.