Evidence map›Paper›PMID 41687619›Full record

ArticleStem cell reports2026

Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period.

Sree Vani Poorna Pillutla, Maddy J Skoda, Atsushi Ishii, Kelsey Bernard, Mandi J Corenblum, Tyler Montgomery, Paige Wene, Nainika Menakuru, Jennifer N Kraszewski, Dean Billheimer and 3 more

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In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sree Vani Poorna PillutlaClinical Translational Sciences Graduate Program, University of Arizona, Tucson, AZ, USA.
Maddy J SkodaPhysiological Science Graduate Program, University of Arizona, Tucson, AZ, USA.
Atsushi IshiiDepartment of Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Kelsey BernardDepartment of Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Mandi J CorenblumDepartment of Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Tyler MontgomeryMolecular Cellular Biology Program, University of Arizona, Tucson, AZ, USA.
Paige WeneMicrobiology Program, University of Arizona, Tucson, AZ, USA.
Nainika MenakuruNeuroscience and Cognitive Science Program, University of Arizona, Tucson, AZ, USA.
Jennifer N KraszewskiStatistical Consulting Lab, BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Dean BillheimerStatistical Consulting Lab, BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Gabriel M WinterDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Stephen L CowenDepartment of Psychology, University of Arizona, Tucson, AZ, USA; Evelyn F McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
Lalitha MadhavanDepartment of Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA; Evelyn F McKnight Brain Institute, University of Arizona, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA. Electronic address: lmadhavan@arizona.edu.

Funding

MARC Biomedical Research and Training Program at the University of ArizonaT34GM149482 · NIGMS · UNIVERSITY OF ARIZONA · PI Katrina M. Miranda · 2023 to 2026
$1.9M
NIGMS NIH HHS T34 GM149482
6 · The paper itself

Abstract

Effects of aging on neural stem progenitor cells (NSPCs) have been studied in males, but less is known in females. Here, we comparatively assess female NSPC biology, both in the subventricular zone and hippocampal dentate gyrus niches, across different age groups of F344 rats. The rats underwent ovariectomy (OVX) or remained Intact at each of the aging stages, to assess the role of the female sex hormones, estradiol (E2) and progesterone (P4). Results show that while age-dependent decays become prominent at 14 months, ovariectomy-induced E2/P4 loss markedly reduces neurogenesis and associated behavioral function, earlier, at 9 months of age. Alongside this, we also detected adaptive changes in estrogen and P4 receptor expression and antioxidant expression. E2/P4 treatment rescued the OVX-induced compromise in neurogenesis and behavior at 9 months. Fundamentally, these results reveal specific female time periods, when the brain is sensitive to age and E2/P4 loss, potentially "setting up" for disease susceptibility.

Indexed as

AgingEstradiolNeurogenesisProgesteroneStem Cell NicheAnimalsDentate GyrusFemaleNeural Stem CellsOvariectomyRatsRats, Inbred F344Receptors, ProgesteroneEstradiolProgesteroneReceptors, Progesteroneagingfemale F344 ratsfemale sex hormoneshippocampusneural stem cellsneurogenesisovariectomysubgranular zonesubventricular zone

Identifiers

PMID41687619
PMCPMC12985377

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.