ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026
Exosome-mediated antiviral testing system and identification of Punicalagins and Anthocyanidins as promising antiviral agents against SARS-CoV-2.
Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Antiviral potential of black tea and blueberry extracts against monkeypox virus by targeting orthopoxvirus surface proteins.Current research in microbial sciences · 2026Article
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13 authors.
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Abstract
Emerging viral infections like SARS-CoV-2 (SCV-2) highlight the need for effective antiviral therapies. We aimed to establish a biosafety level 2 (BSL-2) compatible screening platform using an exosome-polyethylenimine based gene delivery matrix (EPM) to evaluate plant-derived polyphenols for their antiviral potential against SCV-2. EPM platform, facilitates the transfection of plasmid DNA encoding SCV-2 spike, nucleocapsid, and RNA-dependent RNA polymerase (RdRp) proteins into the HEK293T cells, enabling the screening of plant polyphenols for their antiviral activity. Punicalagins (PC), anthocyanidins (Anthos), delphinidin, and cyanidin, completely inhibited viral gene expression. These compounds protected Vero E6 cells from SCV-2 induced cytopathic effects with EC₅₀ values of 18.42 μM, 72.9 μM, and 72.54 μM, respectively. Docking studies revealed strong binding affinities of PC to SCV-2 spike, nucleocapsid, angiotensin-converting enzyme 2 (ACE2) and RdRp proteins (-7.1, -8.0, -10.3 and -10.3 kcal/mol, respectively). In vivo, PC provided dose-dependent protection in K18-hACE2 mice infected with SCV-2. Viral titers in nasal turbinates and lungs reduced by 30-40 % at 6 mg/kg and by 80 % at 12 mg/kg after 5 and 10 days of treatment. These findings support the utility of EPM as a screening platform and establish PC and Anthos as promising antiviral candidates against SCV-2 and other viruses utilizing similar entry mechanism.
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