ArticleJournal of Ayurveda and integrative medicine
Comparative efficacy of andrographolide and hordenine in the treatment of methicillin resistant Staphylococcus aureus infected wounds: a multifaceted approach.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWound healing is a multifaceted biological process hindered by infections, especially the methicillin-resistant Staphylococcus aureus (MRSA), which resists antibiotics. Natural compounds such as andrographolide and hordenine are being explored as alternative therapeutics.
objectiveTo compare the efficacy of andrographolide and hordenine in promoting wound healing in MRSA-infected infectious wounds using in vitro and in vivo methods.
methodsL929 fibroblast-based MTT and scratch assays assessed cytotoxicity and wound closure potential. CAM assay evaluated angiogenic activity. Wistar rats with MRSA-infected excision wounds were treated topically, followed by biochemical analysis (hydroxyproline and hexosamine levels) and histopathological evaluation.
resultsThe study revealed that andrographolide showed significantly (P < 0.001) higher cellular viability than hordenine and significantly reduced the cellular gap in L929 cells by day 3. Andrographolide increased blood vessels significantly (P < 0.001) more than hordenine. Clinical observations indicated reduced pus in andrographolide and hordenine-treated groups than in the control group, with the ceftriaxone-sulbactam group showing the lowest pus formation. Hexosamine levels were comparable in both treatments, while hydroxyproline was higher in the hordenine group. Histopathology showed hordenine-treated animals had faster wound healing and enhanced epithelialisation compared to andrographolide-treated animals.
conclusionAndrographolide and hordenine exhibited wound healing activity in MRSA-infected wounds, promotes fibroblast proliferation and migration, as well as fostering angiogenesis.
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