Evidence map›Paper›PMID 41686904›Full record

ArticleScience advances2026

Munc13-1 couples DAG and Ca

Mrinalini Ranjan, Kun-Han Lin, Brian D Mueller, Sonja M Wojcik, Mareike Lohse, Thomas C Südhof, Erik M Jorgensen, Erwin Neher, Noa Lipstein, Nils Brose and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mrinalini RanjanDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0003-4310-3811
Kun-Han LinLaboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0002-0462-5855
Brian D MuellerHoward Hughes Medical Institute (HHMI), School of Biological Sciences, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6525-7101
Sonja M WojcikDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Mareike LohseDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0009-0001-5149-7833
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3361-9275
Erik M JorgensenHoward Hughes Medical Institute (HHMI), School of Biological Sciences, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-2978-8028
Erwin NeherLaboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0002-9758-7922
Noa LipsteinDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0002-0755-5899
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0003-0938-8534
Holger TaschenbergerDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0003-3186-3231

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic strength and plasticity are fine-tuned by neuromodulation and use-dependent second-messenger signaling. Presynaptic diacylglycerol (DAG), Ca

Indexed as

Calcium SignalingDiglyceridesNerve Tissue ProteinsNeuronal PlasticitySynaptic VesiclesAnimalsCalciumMiceSynapsesSynaptic TransmissionCalciumDiglyceridesNerve Tissue ProteinsUnc13a protein, mouseUnc13c protein, mouse

Identifiers

PMID41686904
PMCPMC12904202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.