ReviewScience advances2026
Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function.
Review in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Thymic Involution and Function in People With HIV and General Population Controls: A Cross-Sectional Analysis From Two Danish Cohort Studies.Aging cell · 2026Article
- Thymic function as a central determinant of immune competence and clinical outcomes.Seminars in immunopathology · 2026Review
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- What Do We Know About Immune System Aging from Human and Animal Studies?International journal of molecular sciences · 2026Review
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- Radiographic evidence of thymic involution in hepatocellular carcinoma: a propensity score-matched study in viral cirrhosis.Frontiers in immunology · 2026Article
- Vitamin D signaling in thymic development and longevity.Frontiers in nutrition · 2026Article
- Mechanism and intervention strategy of thymus atrophy in cancer immunotherapy.American journal of cancer research · 2026Review
- Aging and vaccines: impact of immunosenescence and inflammaging in vaccine response.Frontiers in aging · 2026Review
- Editorial: Thymus research and development: a new look at the past, current knowledge, and future perspectives.Frontiers in immunology · 2026Article
- Network-orchestrated regulation of thymic dysfunction and restoration.Frontiers in immunology · 2026Review
- Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gradual decline in thymic function with age, known as age-related thymic involution, leads to reduced T cell production, thereby increasing the risk of infections and cancer susceptibility and leading to poor vaccine responses. Moreover, T cell defects were recently involved in the age-related loss of tissue integrity and function. Mechanistically, thymic involution is driven by several factors, including hormonal modifications and chronic inflammation, leading to functional changes in the hematopoietic and stromal compartments. These progressive changes alter the cross-talk between developing T cells and thymic epithelial cells, which is pivotal for thymic function. Promising strategies to counteract thymic involution and rejuvenate immune T cell function have been recently identified. This review summarizes key insights into the underlying mechanisms of thymic involution and discusses current and emerging rejuvenation strategies to restore thymic function. These interventions show promise in regenerative medicine to promote healthy aging by alleviating age-associated immune decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.