Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Kapil SirohiDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.ORCID 0000-0001-5039-2848
Anand SripadaDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Mukesh VermaDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.ORCID 0000-0003-0860-9905
Rangati VarmaDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Sucai LiuDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Sangya YadavDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Anita SahuDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Laurie MankaDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Vamsi P GunturDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.ORCID 0000-0002-3210-8265
Magdalena M GorskaDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.ORCID 0000-0001-7364-8703
Rafeul AlamDivision of Allergy and Immunology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.ORCID 0000-0001-8562-4207
Funding
ILC2 memory in asthmaR01AI157138 · NIAID · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2020 to 2024
$3.1M
NIAID NIH HHS R01 AI157138
6 · The paper itself
Abstract
Chromobox protein-7 (CBX7) functions as a gene repressor. We, unexpectedly, found that CBX7 formed a methylation-dependent transcriptional complex, which induced gene transcription by binding to cytokine gene promoters. CBX7 translocated to the cytosol and formed a methylation-dependent signaling complex with c-Raf, MAPK (mitogen-activated protein kinase) kinase 1/2 (MEK1/2), and casein kinase-2 (CK2)-α to generate and sustain extracellular signal-regulated kinase 1/2 (ERK1/2) signaling.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
CBX7 functions as a methylation-dependent inducer of gene transcription and regulator of cytosolic signaling in lymphoid cells. · full record | OpenQuestion