ReviewMicrobiology (Reading, England)2026
Microbial Primer: Bacterial DNA supercoiling.
Review in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
1 author.
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Abstract
DNA in most bacterial cells is maintained in an underwound state. The DNA double helix responds to underwinding by adopting a minimum energy conformation through the supercoiling of the duplex, the formation of local single-stranded bubbles or a combination of both. This Microbiology Primer summarizes the key topological features of DNA and describes the topoisomerase enzymes that manage bacterial DNA topology. The influences of variable DNA topology on transcription and of transcription (and DNA replication) on DNA topology are also discussed. Finally, the article considers the impact of changes in bacterial metabolism and physiology on DNA topology and their implications for bacterial pathogenesis.
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Registered trials
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