ArticlePLOS digital health2026
The three-dimensional landscape of tumor-associated macrophages in reactive and neoplastic human lymph nodes.
Article in PLOS digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Macrophages play a crucial role in the homeostasis of lymph nodes. Their phenotypes and functions are dictated by the molecular composition of the microenvironment. The presence of tumor cells can influence the microenvironment, leading to changes in the cellular functions of tumor-associated macrophages (TAMs). Cellular alterations often correlate with histomorphometric and distributional changes. This study aims to characterize these pathomic modifications resulting from tumor cell infiltration by comparing them to reactive conditions. We assessed CD68+ and CD163+ TAMs in 160 three-dimensional (3D) images of human lymphoid tissue sections derived from 82 cases comprising six different diagnoses. To investigate TAM profiles, we employed a hybrid approach involving computer vision and graph theoretical algorithms. For calculating the histomorphometric features of TAMs, we utilized an image analysis pipeline with IMARIS Advanced Tracking Software. The distributions of TAMs were characterized using cell graphs. The incorporation of 3D tissue analysis in targeted areas of thick tissue sections revealed specific patterns of histomorphometric and distributional changes in TAMs. In chronic lymphocytic leukemia and diffuse large B-cell lymphoma, these distinctive alteration patterns demonstrated entity specificity. Furthermore, pathomic alterations displayed possible correlations with established functional aberrations in lymphomas. These findings imply that the pathomic properties of TAMs mirror their functional aberrations. Through validation and generalization via molecular pathological examinations, this approach has the potential to unveil and understand functional aberrations in histopathological assessments.
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