ArticleCell reports2026
Hypoxia restores the acidosis-induced inhibition of cancer cell dissemination.
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In one paragraph
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Protocol for optogenetic stimulation of cells under physical confinement.STAR protocols · 2026Article
- Galvanin: a molecular compass for bioelectric navigation.Cell research · 2026Article
- Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer.Journal of translational medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Se Jong LeeDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Alice AmitranoDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Qinling YuanDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Debanik ChoudhuryDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Konstantin StoletovDepartment of Oncology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Bhawana AgarwalDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Avery TranDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Inês GodetDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
James McCannDepartment of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Ryan HuizarDepartment of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Selma A SerraLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Pol Picón-PagèsLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Norbert VallesSchool of Sustainable Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK 73019, USA.
Sangmoo JeongDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Stavroula SofouDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Chen-Ming FanDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA.
John D LewisDepartment of Oncology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Sean X SunDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Andrew J EwaldDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Giovanis Institute for Translational Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Daniele M GilkesDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Cellular and Molecular Medicine Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Vivek K BajpaiSchool of Sustainable Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK 73019, USA; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Miguel A ValverdeLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: konstant@jhu.edu.
Funding
The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasisR01CA254193 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, MARTIN, STUART S · 2021 to 2025
$2.7MMapping the single cell state basis of metastasis in space and timeU01CA284090 · NCI · JOHNS HOPKINS UNIVERSITY · PI Andrew Josef Ewald · 2023 to 2026
$2.7MViscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosityR01CA257647 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2021 to 2025
$2.3MMetabolic regulation of exosome biogenesisR35GM147513 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Sangmoo Jeong · 2022 to 2026
$2.3MThe interplay of extracellular fluid viscosity, stiffness and confinement in regulating cell responsesR35GM156305 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Konstantinos Konstantopoulos · 2025 to 2026
$959kNCI NIH HHS R01 CA254193NCI NIH HHS R01 CA257647NCI NIH HHS U01 CA284090NIGMS NIH HHS R35 GM147513NIGMS NIH HHS R35 GM156305
Abstract
Acidosis is a hallmark of the tumor microenvironment and has been linked to aggressive cancer behavior, characterized by increased migration, invasion, and metastasis. We herein demonstrate that short-term exposure (24-72 h) to acidic extracellular pH (pH
Indexed as
AcidosisNeoplasmsAdaptor Proteins, Signal TransducingAnimalsCell HypoxiaCell Line, TumorCell MovementCell ProliferationChick EmbryoHumansHydrogen-Ion ConcentrationMicePhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAdaptor Proteins, Signal TransducingPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesScaffold Protein ILKSodium-Hydrogen Exchanger 1acidosisAktcancerCP: cancerCP: metabolismglycolysishypoxiaintegrin-linked kinasemigrationNHE1reactive oxygen speciesYAP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.