ArticleMedicine2026
Comparative evaluation of liraglutide plus metformin combination therapy versus metformin monotherapy in patients with type 2 diabetes mellitus: A retrospective clinical study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Durable glycemic control remains challenging in patients with type 2 diabetes mellitus inadequately controlled with metformin alone. Liraglutide, a glucagon-like peptide-1 receptor agonist, has been proposed as a beneficial add-on therapeutic option. This retrospective study included adults with type 2 diabetes mellitus treated between March 2021 and March 2025. Patients were divided into a combination group receiving liraglutide plus metformin and a control group receiving metformin alone. Glycemic parameters and safety outcomes were assessed at baseline and after 6 months of treatment. Statistical comparisons were conducted using Welch t test and Chi-square or Fisher exact test. A total of 207 patients were analyzed. Compared with metformin monotherapy, combination therapy achieved greater reductions in glycated hemoglobin (-1.8 ± 0.9% vs -1.3 ± 0.8%; P < .001), fasting and postprandial plasma glucose, fasting insulin, and homeostasis model assessment of insulin resistance. The proportion achieving composite glycemic targets was higher in the combination group (76.5% vs 57.9%; P = .006). Adverse event incidence and treatment discontinuation did not differ significantly between groups. Liraglutide add-on therapy provided superior glycemic improvement compared with metformin alone and demonstrated acceptable safety and tolerability.
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