Evidence map›Paper›PMID 41686525›Full record

ArticleJournal of breast imaging2026

Prone-to-Supine Breast MRI for Tumor Margin Visibility and Surgical Guidance.

Roberta M diFlorio-Alexander, Brook Byrd, Venkat Krishnaswamy, Misty Fox, Keith Paulsen, Richard J Barth, Timothy Rooney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of breast imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roberta M diFlorio-AlexanderDepartment of Radiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.ORCID 0000-0003-0589-8158
Brook ByrdDepartment of Radiology, Penn Medicine, Philadelphia, PA, USA.
Venkat KrishnaswamyCairnSurgical Inc, Lebanon, NH, USA.
Misty FoxCairnSurgical Inc, Lebanon, NH, USA.
Keith PaulsenThayer School of Engineering at Dartmouth, Dartmouth College, Hanover, NH, USA.
Richard J BarthGeisel School of Medicine at Dartmouth, Hanover, NH, USA.
Timothy RooneyDepartment of Radiology, University of Virginia, Charlottesville, VA, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Supine Breast MRI Standardization for Breast Cancer LocatorR44CA232862 · NCI · CAIRNSURGICAL, INC. · PI KRISHNASWAMY, VENKATARAMANAN · 2018 to 2020
$2.2M
Breast Cancer LocatorR44CA210810 · NCI · CAIRNSURGICAL, INC. · PI KRISHNASWAMY, VENKATARAMANAN · 2017 to 2018
$2.0M
Randomized Prospective Trial of Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast CancerR44CA247124 · NCI · CAIRNSURGICAL, INC. · PI KRISHNASWAMY, VENKATARAMANAN · 2020 to 2021
$2.0M
National Cancer Institute Small Business Innovation Research R44CA210810National Cancer Institute Small Business Innovation Research R44CA232862NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA210810NCI NIH HHS R44 CA232862NCI NIH HHS R44 CA247124
6 · The paper itself

Abstract

backgroundSupine breast MRI reproduces the surgical position during breast-conserving surgery, with early studies reporting the benefit of decreased positive margin rates. However, acquiring an additional contrast-enhanced supine breast MRI after a prone breast MRI in a second imaging session is clinically and financially challenging. The aim of this study was to evaluate the tumor-to-fibroglandular tissue contrast ratios and the ability to visualize tumor margins in a double-bolus prone-to-supine breast MRI obtained in a single imaging session.

methodsThirty-nine patients with breast cancer had a standard prone breast MRI followed immediately by a second contrast injection in the supine position to obtain supine breast MRI (double-bolus prone-to-supine MRI protocol [P2S2]). A control group of 35 patients received a prone examination and an independent supine examination in 2 separate imaging sessions. Tumor-to-fibroglandular tissue contrast ratios (TFRs), a measure of tumor enhancement that informs the ability to visualize tumor margins, were statistically compared between cohorts. Two radiologists independently rated the ability to visualize tumor margins in the independent and double-bolus supine breast MRIs.

resultsNo significant differences were found in the mean TFR between the independent and P2S2 supine examinations (P = .79). Excellent agreement occurred between both readers regarding the ability to visualize the tumor margins in the independent and P2S2 supine MRIs with κ scores of 1.00 and 0.95, respectively.

conclusionA supine breast MRI obtained in a single imaging session after a second contrast injection provided adequate tumor enhancement for tumor margin visualization and preoperative surgical guidance comparable with independent supine breast MRI.

Indexed as

Breast NeoplasmsMagnetic Resonance ImagingMargins of ExcisionPatient PositioningSurgery, Computer-AssistedAdultAgedBreastContrast MediaFemaleHumansMastectomy, SegmentalMiddle AgedProne PositionSupine PositionContrast Mediabreast cancerpreoperative supine breast MRIsurgical guidance

Identifiers

PMID41686525
PMCPMC13025332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.