Trial reportInternational forum of allergy & rhinology2026
Effect of Budesonide Nasal Irrigation in Patients With Chronic Rhinosinusitis With Nasal Polyps Without Prior Sinus Surgery: A Randomized, Double-Blind, Placebo-Controlled Study.
Trial report in International forum of allergy & rhinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comment on "Effect of Budesonide Nasal Irrigation in Patients With Chronic Rhinosinusitis With Nasal Polyps Without Prior Sinus Surgery: A Randomized, Double-Blind, Placebo-Controlled Study".International forum of allergy & rhinology · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundThe indication for nasal irrigation with corticosteroids after sinus surgery in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is well established, as surgery facilitates distribution throughout the sinonasal cavity. However, it remains unknown whether this approach could also provide therapeutic benefit prior to surgery. This study aims to compare the effect of budesonide versus saline nasal irrigation in surgically naive CRSwNP patients.
methodsA randomized, double-blind, placebo-controlled parallel-group study was conducted in 52 patients with diffuse type 2 CRSwNP with no previous sinus surgery. Patients were randomized to receive either 1 mg budesonide or saline nasal irrigation twice daily for four weeks. The primary outcome was the change in the 22-item Sinonasal Outcome Test (SNOT-22). Secondary outcomes included the Visual Analogue Scale (VAS), Nasal Polyp Score (NPS), and the Connecticut (CCCRC) olfactory test.
resultsA total of 52 patients were randomized (mean age 50.1 ± 12.9 years; 51.9% female). The intention-to-treat (ITT) analysis showed that the budesonide nasal irrigation group demonstrated a significantly greater improvement in SNOT-22 (mean difference: 18.1 points [95% CI: 3.4 to 32.8; p = 0.017]), VAS (mean difference 2.24 points [95% CI: 0.35 to 4.13; p = 0.018]) and NPS (mean difference: 0.73 points [95% CI: 0.25 to 1.21]; p = 0.003). No significant differences were observed between groups in CCCRC.
conclusionBudesonide nasal irrigation may be an important tool for controlling sinonasal symptoms in patients with CRSwNP who are not candidates for sinus surgery or while awaiting surgical treatment.
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