Evidence map›Paper›PMID 41686493›Full record

Observational studyFunction (Oxford, England)2026

Epigenetic modifications of VEGF, cerebral hypoxia, and impaired cerebrovascular autoregulation as early indicators for preterm brain injury.

Celina L Brunsch, Daphne H Klerk, Dorian Blommaert, Richelle G Harbers-Middel, Bineta E Lahr, Annemiek M Roescher, Torsten Plösch, Elisabeth M W Kooi

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Celina L BrunschDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-3394-7423
Daphne H KlerkDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dorian BlommaertDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Richelle G Harbers-MiddelDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bineta E LahrDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Annemiek M RoescherDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Torsten PlöschDepartment of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Elisabeth M W KooiDivision of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodevelopmental impairments after preterm birth remain prevalent. Preterm brain injury, such as intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), occurs due to immature vascularization and impaired cerebral blood flow. We explored epigenetic changes in the vascular endothelial growth factor A (

Indexed as

Brain InjuriesCerebrovascular CirculationEpigenesis, GeneticLeukomalacia, PeriventricularVascular Endothelial Growth Factor ABiomarkersDNA MethylationFemaleGestational AgeHomeostasisHumansInfant, NewbornInfant, PrematureMaleProspective StudiesBiomarkersVascular Endothelial Growth Factor AVEGFA protein, humanDNA methylationepigeneticsneurodevelopmentpreterm birthvascular endothelial growth factor

Identifiers

PMID41686493
PMCPMC13249037

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.