Observational studyAdvances in therapy2026
Real-World Clinical Outcomes and Treatment Patterns in Advanced/Metastatic EGFR-Mutant NSCLC After Progression on First-Line Osimertinib for French Patients.
Observational study in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03848052 (Epidemiological Strategy and Medical Economic), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiological Strategy and Medical Economic (ESME) Research Program / Academic Real World Data Platform: Evolution of the Therapeutic Care in Lung Cancer in France Since 2015
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0 citing papers in PubMed.
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOsimertinib, a third-generation tyrosine kinase inhibitor (TKI), is a standard first-line (1L) treatment for advanced/metastatic EGFR non-small cell lung cancer (NSCLC). Despite improved overall survival (OS) and progression-free survival (PFS) compared to earlier generation TKIs, resistance and disease progression are common. No standardized second-line (2L) treatment exists for patients who progress after 1L osimertinib. This study assessed real-world (rw) treatment patterns and clinical outcomes in French patients with advanced/metastatic NSCLC who received 2L therapy post-osimertinib progression.
methodsThis retrospective, observational study used the Epidemio-Strategy and Medical Economics (ESME) LC database (NCT03848052) (January 1, 2015-2023; data extraction September 2023). Patients ≥ 18 years with confirmed advanced/metastatic NSCLC, treated with 1L osimertinib, and documented 2L therapy were included. The study assessed patient characteristics, rw treatment patterns, rwOS, and rwPFS.
resultsAmong 284 patients (71.1% female, median age 67), 67% initiated 2L treatment in 2021 or later. The median number of metastases at 2L initiation was three, with bone (65.1%) and brain (56.6%) as the most common sites; 34% of brain metastases were symptomatic. The 2L treatments included platinum-based chemotherapy (50%), EGFR TKI-based therapy (29.9%), immunotherapy (9.9%), and other regimens (10.2%). Median rwOS from 2L initiation was 10.1 (95% CI 9.2-12.1) months, and median rwPFS was 4.1 (95% CI 3.3-4.8) months. Among patients with brain metastases, median rwOS was 8.7 (95% CI 7.1-11.9) months for asymptomatic and 10.7 (95% CI 9.4-12.9) months for symptomatic patients vs 11.8 (95% CI 9.1-17.4) months in patients without brain metastases. Patients with liver metastases had a median rwOS of 8.2 (95% CI 6.4-9.6) months vs 12.3 (95% CI 10.2-14.3) months in those without.
conclusionsClinical outcomes for patients receiving 2L therapy post-osimertinib progression remain poor, highlighting an unmet need, particularly for those with brain and liver metastases.
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